A newly discovered long noncoding RNA lnc-FANCI-2 suppresses RAS signaling to modulate Akt and Erk1/2 phosphorylation in high-risk HPV cervical cancer, consequently regulating HPV carcinogenesis.
Melanie Rose Walker, Preston Leung ... Rowena A Bull
Early immune pressure and co-occurring mutations drive changes in hepatitis C virus fitness and evolution, revealing key dynamics in the establishment of chronic infection.
Engineering self-amplifying RNA to intrinsically disarm the innate immune pathways it triggers enables durable, externally controlled gene expression with reduced cytotoxicity and cytokine release, eliminating the need for exogenous immunosuppressants.
Kevin Sung, Mackenzie M Johnson ... Frederick A Matsen
Convolutional embedding models efficiently capture wide sequence context in antibody somatic hypermutation, avoiding exponential k-mer parameter scaling and eliminating the need for per-site modeling.
Connor Hill, Alexandra Indeglia ... Alessandro Gardini
Molecular profiling with omics approaches reveals the resemblance between neuroendocrine malignancies and solitary fibrous tumors, rare soft tissue cancers with no effective treatment options.
Thermal imaging, computer vision tools, and an open-source algorithm incorporating a transformer-based video classifier are combined to automatically detect and classify urine and fecal deposits made by male and female mice and their spatio-temporal dynamics during behavioral tests.
Bárbara Pinto-Correia, Patrícia Caldeira-Bernardo, Miguel Remondes
Light-activating a proton pump (eArchT) to silence hippocampal synaptic terminals in the rodent retrosplenial cortex caused a spatial working memory impairment affecting interleaved trials where no light was delivered.
Reinforcement motor learning of probabilistic tasks shows a protracted developmental trajectory in childhood due to high motor noise and low exploration, though performance deficits can be ameliorated in younger children by reducing task demands in spatial processing and probabilistic reasoning.
Alexander L Tesmer, Paulius Viskaitis ... Denis Burdakov
Orexin neurons precisely track body movement across behavioral and metabolic states, revealing a neural mechanism that links motor activity to arousal and energy resources.
Reversible synaptic plasticity between sensory neurons and interneurons, switching between inhibitory and excitatory, underpins the neural basis of salt concentration memory-dependent preference reversal in Caenorhabditis elegans.
Enalapril combats the effects of senescence by activating the pSmad1/5/9–antioxidative gene axis, enhancing antioxidative defenses and promoting cell proliferation, thereby supporting healthy aging.
Eloise Giraud, Michael Lynn ... Jean-Philippe Thivierge
A novel software tool and ground-truth optogenetic validation is provided to automatically detect putative excitatory and inhibitory cells in neuronal recordings performed with large-scale multielectrode arrays.
It is proposed that innate immune cells are positioned to activate the naïve B cell repertoire and rational application of training stimuli could enforce this, offsetting original antigenic sin, wherein recall of ‘off-target’ B cell memory can obscure vaccine effectiveness.
Jessica Mella, Regan F Volk ... Abigail Buchwalter
The inner nuclear membrane protein emerin readily traffics through the secretory pathway via its hydrophobic transmembrane domain when tagged with C-terminal GFP.
The complete synaptic connectome and the comprehensive annotation of all cell types based on a whole-body electron microscopy volume of an annelid larva.
Clinical, genetic, and model organism data collectively define PLCG1 as a disease-associated gene with diverse missense variants contributing to phenotypic heterogeneity.
The unbiased genetic screening and animal model experiments have characterized a new candidate pathogenic gene associated with high myopia, providing a potential therapeutic intervention target for controlling the disease.
Laura Dovek, Mahboubeh Ahmadi ... Vijayalakshmi Santhakumar
Evaluation of semilunar granule cell involvement in dentate gyrus contextual memory processing supports recruitment based on intrinsic and input characteristics while revealing limited contribution to ensemble refinement.
NOLC1 inhibits p53 nuclear accumulation and transcription, subsequently suppresses cisplatin-induced ferroptosis, and promotes an immunosuppressive microenvironment, eventually suppressing immunochemotherapy in gastric cancer.
Following chronic hyperactivation using chemogenetics, vulnerable substantia nigra dopamine neurons display progressive degeneration unlike neighboring ventral tegmental area dopamine neurons.
Behavioural patterns among female gorillas indicate that animals guide their aggressive interactions towards more or less powerful groupmates depending on the conditions they experience.
Functional organoids prepared from chicken embryonic gut consisting of pacemaker cells and smooth muscles undergo periodic contractions, offering a useful tool to understand rhythm control in multicellular systems.
KLF2 activity and impaired interferon signaling contribute to HIV-1 persistence by restricting antiviral immunity in infected CD4 T cells during early infection.
COMMD3 regulates endosomal trafficking outside the Commander holo-complex, revealing that a trafficking complex subunit can function independently of the entire complex.
Johannes Jacobus Fahrenfort, Philippa A Johnson ... Simon van Gaal
This response counters arguments given in a commentary by Sandberg and Overgaard, 2025 regarding an article in eLife about criterion confounds in neural measures of consciousness based on subjective measures by Fahrenfort et al, 2025.
A versatile computational framework realistically simulates fluorescence lifetime data in biological systems, enhancing rigor by quantifying signal variance and identifying limitations, and enabling innovations such as multiplexed dynamic biosensor imaging.
Disrupting full-length BEND2 impairs ovarian reserve establishment without causing male sterility, highlighting a sex-specific role in fertility and offering new insights into genetic contributions to infertility diagnosis and reproductive health.
The substantia nigra inhibits all PPN neurons and causes place aversion, while the globus pallidus selectively inhibits caudal non-cholinergic PPN neurons and causes place preference.
Maria Ardaya, Marie-Catherine Tiveron ... Fabio Cavaliere
A population of ischemia-induced newborn astrocytes, positive for Thbs4, that migrate to the lesion border, where they produce and degrade hyaluronan, modulating the local extracellular matrix, has been identified.
Souleymane Diallo, Kateřina Kašparová ... Robert Hanus
Identification of the trail-following pheromone receptor in the termite Prorhinotermes simplex represents the first functional characterization (deorphanization) of an odorant receptor in termites.
Bing Guo, Shannon Takala-Harrison, Timothy D O'Connor
hmmIBD outperforms alternative tools in detecting genome segments that are identical-by-descent and uncovering signals of positive selection and demographic history in malaria parasite genomes, underscoring the importance of tool prioritization and optimization for reliable malaria genomic surveillance.
Thomas Balligand, Claire Carpenet ... Maarten Dewilde
Two radio-labeled nanobodies and a single knock-in mouse model suffice to track the biodistribution of various unmodified cell-types in live mice by PET/CT.
The cryoEM structure of a RAD51 displacement loop reveals the molecular mechanism of the strand-exchange reaction at the centre of eukaryotic homologous recombination.
Wide-gauge posture in the limb skeleton of Titanosauriformes is an exaptation to gigantism, as it is not correlated with body size in deeply branching titanosaurs.
Rosanna P Sammons, Stefano Masserini ... Dietmar Schmitz
The asymmetric connectivity between thorny and athorny pyramidal neurons in the CA3 region is the key in maintaining the separation of peak firing during sharp wave events.
Population trajectories of premotor cortex mirror neurons progress through distinct subspaces during execution versus observation of reach-grasp-manipulate movements, yet latent dynamics can be aligned, indicating similar relationships among neural representations.
Janelle JY Chuah, Madalena R Daugherty, David M Smith
A single hydrophobic interaction drives allosteric gate-opening of the archaeal 20S proteasome, identifying a specific new target for therapeutic drug design.
YEATS2 and GCDH are upregulated in head and neck cancer in an SP1-dependent manner, leading to enhanced levels of promoter histone crotonylation which in turn elevates expression of EMT-associated SPARC.
Ruggiero Francavilla, Bidisha Chattopadhyaya ... Graziella Di Cristo
Syngap1 haploinsufficiency, which is associated with intellectual disability, epilepsy, and other cognitive and behavioral impairments, reduces the firing and excitatory drive of cortical interneurons.
Glycolysis and attenuates oxidative phosphorylation through long-chain fatty acids, while mitochondrial biogenesis and anabolism remain intact, to accelerate the progression of acute megakaryocytic leukemia.
D2-like receptors in a pair of dopamine DAN-c1 neurons drive aversive learning, while those in mushroom body neurons mediate both aversive and appetitive learning in Drosophila larvae.
A time-course RNA-seq analysis of muscle remodeling reveals transcriptional dynamics independent of autophagy and highlights the significance of BNIP3 in mitochondrial degradation in vivo.
Marie-Alphée Laurent, Corentin Jacques ... Bruno Rossion
There is a striking correspondence between face-selective neural increases vs decreases of fMRI BOLD signal and spikes in neighboring human fusiform gyrus regions.
Marc W Schmid, Klara Kropivšek ... Ueli Grossniklaus
Strong selection by aphids only weakly affects epigenetic and phenotypic variation within three Arabidopsis thaliana accessions, demonstrating limited potential for adaptation by epigenetic differentiation within genotypes in this model species.
Anna Pakula, Salsabiel El Nagar ... Alexandra L Joyner
During cerebellum regeneration following injury, reactive oxygen species are implicated as enhancing the adaptive reprogramming response that contributes to replenishment of granule cell progenitors that are killed.
The combination of histological and microscopic techniques, along with the initial application of finite-difference time-domain (FDTD) modeling to a fossil feather, has resulted in the first recovery of specific iridescent color patterns.
Mendelian randomization offers novel insights into the genetic factors that influence the aging process through early-life reproductive events, providing robust evidence for the antagonistic pleiotropy theory in humans.
Irina Kalita, Ira Alexandra Iosub ... Meriem El Karoui
Single-molecule mRNA and protein quantification, combined with stochastic modelling, uncover a post-transcriptional regulatory mechanism that controls the expression of the extremely low-abundance DNA double-strand break repair enzyme RecBCD.
Depletion of Dynamin-related protein 1, a key regulator of mitochondrial fission, in mouse zygotes impair symmetric organelle partitioning and chromosome segregation leading to early developmental arrest.
Hexokinases regulate the metabolic transcription factor MML-1 via distinct pathways, linking glucose metabolism and organellar signaling to longevity control in Caenorhabditis elegans and mammals.
Certain bacteriophage are specifically adapted to infecting biofilm bacteria by exploiting biofilm characteristics, such as the exopolysaccharides produced by bacteria in biofilms.
The rapid development of pesticide resistance in a mite across wide geographical areas is linked to the independent and repeated emergence of multiple mutations in target genes.
Motile Enterobacteriaceae override chemorepulsion from the microbiota metabolite indole in favor of nutrient attraction, challenging the idea that indole taxis protects the host against intestinal infection.
A novel, non-invasive strategy combining radiomics and blood extracellular vesicle-derived microRNA profiling to sharpen pancreatic cancer diagnosis is introduced.
Live imaging allows tracking cellular behaviours and cell fates during the entire course of leg regeneration, spanning approximately one week, in a crustacean model.
Probiotic P118 against Salmonella infections by directly antibacterial actions, inhibiting Salmonella colonization and invasion, attenuating macrophage pro-inflammatory responses, and modulating gut microbiota mediated by microbe-derived indole metabolites.
Dominic WH Shayler, Kevin Stachelek ... David Cobrinik
Full-length single-cell RNA-sequencing provide insights into the earliest gene expression programs, the distinct mRNA transcript isoforms, and the retinoblastoma-related cell states associated with human cone and rod photoreceptor development.
Christina Alexandra Stephens, Niek van Hilten ... Michael Grabe
The majority of TMEM16 lipid scrambling occurs in the open groove associated with Ca2+ activation, but limited scrambling also occurs in the dimer interface independent of Ca2+.
Keratinocyte cytonemes mediate essential Notch signaling for proper skin maintenance, with their disruption leading to abnormal differentiation and hyperproliferation resembling human skin disease phenotypes.
Exercise intensity alone does not differentially reduce pain, but individual factors like fitness level and sex, along with opioid mechanisms, may influence exercise-induced pain relief.
Isaïh Schwab-Mohamed, Manuel R Mercier ... Daniele Schön
Fine-grained neural dynamics underlying speech coordination are revealed using a real-time interactive synchronous speech task that dissociates functional roles within the dorsal language pathway.
Several studies have now demonstrated that trained immunity occurs in the airways to several pathogens and products, while its utility is yet to be determined.
Increasing CD11c+ microglial subsets in the spinal dorsal horn by intrathecal treatment of interleukin-4 alleviate pain hypersensitivity caused by nerve injury.
Fanny Eggeler, Jonathan Boulanger-Weill ... Filippo Del Bene
Genetic analyses in zebrafish reveal a new role for the Meteorin protein family in the left-right asymmetry patterning during embryonic vertebrate development.
The sense of smell is crucial for insect larvae not only to find a suitable food source but also for finding safe spaces which are free of their natural enemies.
Christopher R Lee, Gillian A Matthews ... Kay M Tye
Optogenetic manipulations and neural circuit interrogation reveal that dorsal raphe dopamine circuits can emulate different facets of a loneliness-like state, including prosociality, aversion, and vigilance.
Abundant single-stranded telomeric DNA distinguishes alternative lengthening of telomeres-positive cells and represents a potential biomarker and therapeutic vulnerability.
