July 2025

Research articles

1. 1. Biochemistry and Chemical Biology

   Concatenated Modular BK Channel Constructs Reveal Divergent Stoichiometry in Gating Control by LRRC26 (γ1), Pore, and Selectivity Filter

   Guanxing Chen, Qin Li, Jiusheng Yan
2. 1. Cell Biology
   2. Immunology and Inflammation

   The Anti-Inflammatory Role of GPNMB in Post-Traumatic Osteoarthritis

   Asaad A Al-Adlaan, Bryson Cook ... Fayez F Safadi
3. 1. Developmental Biology
   2. Stem Cells and Regenerative Medicine

   Smed-pou4-2 regulates mechanosensory neuron regeneration and function in planarians

   Ryan A McCubbin, Mohammad A Auwal ... Ricardo M Zayas
4. 1. Biochemistry and Chemical Biology

   General Trends in the Calnexin-Dependent Expression and Pharmacological Rescue of Clinical CFTR Variants

   Austin Tedman, John A Olson ... Jonathan P Schlebach
5. 1. Ecology
   2. Microbiology and Infectious Disease

   Effects of parental care on skin microbial community composition in poison frogs

   Marie-Therese Fischer, Katherine S Xue ... Lauren A O'Connell

   Direct skin contact during parental care in poison frogs transmits host-adapted microbes to tadpoles, where some bacterial taxa may persist on the skin through early development.
6. 1. Evolutionary Biology

   Trophic eggs affect caste determination in the ant Pogonomyrmex rugosus

   Eléonore Genzoni, Tanja Schwander, Laurent Keller

   Experiments manipulations show that trophic eggs can suppress queen development and therefore regulate caste determination in ants.
7. 1. Biochemistry and Chemical Biology

   Elevated ubiquitin phosphorylation by PINK1 contributes to proteasomal impairment and promotes neurodegeneration

   Cong Chen, Tong-Yao Gao ... Wei-Ping Zhang

   Elevated ubiquitin phosphorylation disrupts proteasomal function, creating a self-amplifying cycle that drives progressive protein aggregation and neuronal injury across multiple neurodegenerative conditions.
8. 1. Epidemiology and Global Health

   Estimating probabilities of malaria importation in southern Mozambique through P. falciparum genomics and mobility patterns

   Arnau Pujol, Arlindo Chidimatembue ... Alfredo Mayor
9. 1. Neuroscience

   Hypothalamic deiodinase type-3 establishes the period of circannual interval timing in mammals

   Calum Stewart, T Adam Liddle ... Tyler J Stevenson
10. 1. Stem Cells and Regenerative Medicine

    Stabilisation of HIF signalling extends epicardial activation and neonatal heart regeneration

    Elisabetta Gamen, Eleonor L Price ... Paul R Riley
11. 1. Cancer Biology

    PA28γ promotes the malignant progression of tumor by elevating mitochondrial function via C1QBP

    Jiongke Wang, Yujie Shi ... Qianming Chen

    The promotion of C1QBP accumulation by PA28γ leads to the malignant progression of tumor by affecting mitochondrial function, which could be a launch pad for therapeutic intervention of tumor development.
12. 1. Neuroscience

    A stochastic explanation for observed local-to-global foraging states in Caenorhabditis elegans

    Andrew Margolis, Andrew Gordus

    Changes in internal state for stochastic behaviors can be more easily explained by a stochastic model with no state change.
13. 1. Neuroscience

    The influence of nucleus accumbens shell D1 and D2 neurons on outcome-specific Pavlovian instrumental transfer

    Octavia Soegyono, Elise Pepin ... Vincent Laurent
14. 1. Physics of Living Systems

    Non-equilibrium strategies for ligand specificity in signaling networks

    Andrew Goetz, Jeremy Barrios ... Purushottam Dixit
15. 1. Genetics and Genomics
    2. Neuroscience

    The C. elegans gustatory receptor homolog LITE-1 is a chemoreceptor required for diacetyl avoidance

    Alan Koh, Eduard Bokman ... André EX Brown
16. 1. Computational and Systems Biology
    2. Physics of Living Systems

    Atypical collective oscillatory activity in cardiac tissue uncovered by optogenetics

    Alexander S Teplenin, Nina N Kudryashova ... Tim De Coster
17. 1. Neuroscience

    Altered reactivity to threatening stimuli in Drosophila models of Parkinson’s disease, revealed by a trial-based assay

    Márton Kajtor, Viktor András Billes ... Balázs Hangya

    An inexpensive, scalable trial-based behavioral assay revealed quantitative difference in fruit flies' escape behavior across different genetic models of neurodegeneration.
18. 1. Genetics and Genomics

    Specific modulation of CRISPR transcriptional activators through RNA-sensing guide RNAs in mammalian cells and zebrafish embryos

    Oana Pelea, Sarah Mayes ... Tatjana Sauka-Spengler

    RNA-sensing guide RNAs provide a programmable platform for conditional, sequence-specific activation of CRISPR-Cas9 upon RNA detection in diverse biological contexts.
19. 1. Cell Biology

    N-cadherin mechanosensing in ovarian follicles controls oocyte maturation and ovulation

    Alaknanda Emery, Orest W Blaschuk ... Darryl L Russell

    A critical role for N-cadherin in ovarian follicular development and ovulation is demonstrated with inhibitors or knockout of N-cadherin shown to inhibit ovulation by blocking mechanotransduction of ovulatory genes.
20. 1. Neuroscience

    Center-surround inhibition by expectation: a neuro-computational account

    Ling Huang, Shiqi Shen ... Xilin Zhang
21. 1. Neuroscience

    Working memory shapes neural geometry in human EEG over learning

    Michał J Wójcik, Amy Li ... Laurence T Hunt
22. 1. Neuroscience

    A theory and recipe to construct general and biologically plausible integrating continuous attractor neural networks

    Federico Claudi, Sarthak Chandra, Ila R Fiete
23. 1. Neuroscience

    A neural mechanism for compositional generalization of structure in humans

    Lennart Luettgau, Nan Chen ... Raymond J Dolan
24. 1. Neuroscience

    Compensation of Hyperexcitability with Simulation-Based Inference

    Daniel Müller-Komorowska, Tomoki Fukai
25. 1. Cell Biology
    2. Neuroscience

    Development of the axonal βII-spectrin periodic skeleton requires active cytoskeletal remodelling

    Shivani Bodas, Ashish Mishra ... Aurnab Ghose
26. 1. Neuroscience

    Economic and Social Modulations of Innate Decision-Making in Mice Exposed to Visual Threats

    Zhe Li, Jiahui Wang ... Ya-tang Li
27. 1. Neuroscience

    Paraventricular Thalamus Hyperactivity Mediates Stress-Induced Sensitization of Unlearned Fear but Not Stress-Enhanced Fear Learning (SEFL)

    Kenji J Nishimura, Denisse Paredes ... Michael R Drew
28. 1. Evolutionary Biology
    2. Genetics and Genomics

    Refining the resolution of the yeast genotype–phenotype map using single-cell RNA-sequencing

    Arnaud N'Guessan, Wen Yuan Tong ... Alex N Nguyen Ba

    Single-cell RNA sequencing of thousands of yeast progeny reveals how gene expression differences and heritability drive phenotypic diversity.
29. 1. Physics of Living Systems

    Optimal information gain at the onset of habituation to repeated stimuli

    Giorgio Nicoletti, Matteo Bruzzone ... Daniel Maria Busiello

    The onset of habituation phenomena enables accurate processing of external stimuli when biological systems adapt their parameters to balance dissipation and the information between input and response.
30. 1. Neuroscience

    Learning place cells and remapping by decoding the cognitive map

    Markus Borud Pettersen, Vemund Schøyen ... Mikkel E Lepperød

    Border cells are sufficient to generate place cells and remapping during path integration in artificial neural networks, challenging the role of grid cells for spatial navigation.
31. 1. Immunology and Inflammation

    Phosphoglycerate mutase regulates Treg differentiation through control of serine synthesis and one-carbon metabolism

    Wesley H Godfrey, Judy J Lee ... Michael D Kornberg

    The glycolytic enzyme phosphoglycerate mutase supports Treg function, identifying a novel therapeutic target for immune modulation and demonstrating that glycolytic regulation of T cells is more nuanced than previously appreciated.
32. 1. Medicine

    Efficacy and safety of neoadjuvant stereotactic body radiation therapy plus dalpiciclib and exemestane for hormone receptor-positive, HER2-negative breast cancer: A prospective pilot study

    Yu Zhang, Shuo Cao ... Caigang Liu

    Neoadjuvant SBRT with dalpiciclib and exemestane resulted in a 16.7% RCB 0-I rate and a 91.7% ORR, with acceptable toxicities in HR-positive, HER2-negative breast cancer patients.
33. 1. Neuroscience

    A computational pipeline to track chromatophores and analyze their dynamics

    Johann Ukrow, Mathieu DM Renard ... Gilles Laurent

    Computer code is provided to track the size and shape of deformable pigment cells in the skin of cephalopods from high-resolution video images.
34. 1. Structural Biology and Molecular Biophysics

    Conduction pathway for potassium through the E. coli pump KdpFABC

    Adel Hussein, Xihui Zhang ... David L Stokes
35. 1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    A biochemical mechanism for Stu2/XMAP215-family microtubule polymerases

    Binnu Gangadharan, Daniel L Kober, Luke M Rice
36. 1. Cell Biology

    The insulin / IGF axis is critically important controlling gene transcription in the podocyte

    Jennifer A Hurcombe, Lusyan Dayalan ... Richard JM Coward
37. 1. Developmental Biology

    Distinct waves of ovarian follicles contribute to mouse oocyte production

    Qi Yin, Allan C Spradling
38. 1. Computational and Systems Biology
    2. Neuroscience

    A SMARTTR workflow for multi-ensemble atlas mapping and brain-wide network analysis

    Michelle Jin, Simon O Ogundare ... Christine Ann Denny

    A new scalable workflow for analyzing multiple ensemble datasets incorporates SMARTTR, an R package supporting network analysis, visualization, and the import of external datasets.
39. 1. Neuroscience

    Cingulate cortex shapes early postnatal development of social vocalizations

    Gurueswar Nagarajan, Denis Matrov ... Yogita Chudasama

    The normal development of social vocal behavior depends on the anterior cingulate cortex and its interaction with the vocal network during early life.
40. 1. Neuroscience

    No effect of additional education on long-term brain structure, a preregistered natural experiment in thousands of individuals

    Nicholas Judd, Rogier Kievit

    There is no discernible effect of an additional year of education from a policy change on long-term structural neuroimaging measures in a large aging sample (UK Biobank).
41. 1. Neuroscience

    Neocortical layer-5 tLTD relies on non-ionotropic presynaptic NMDA receptor signaling

    Aurore Thomazeau, Sabine Rannio ... Per Jesper Sjöström

    Neocortical timing-dependent LTD relies on non-ionotropic presynaptic NMDA receptor signaling via JNK2, challenging the textbook view that NMDA receptors are ionotropic coincidence detectors in Hebbian plasticity.
42. 1. Neuroscience

    Population-level morphological analysis of paired CO₂- and odor-sensing olfactory neurons in D. melanogaster via volume electron microscopy

    Jonathan Choy, Shadi Charara ... Chih-Ying Su

    Homotypic olfactory receptor neurons in Drosophila, including CO₂-sensing neurons with distinctive sheet-like dendrites, exhibit unexpected morphological diversity that may underlie functional adaptability.
43. 1. Neuroscience

    Cell type-specific contributions to a persistent aggressive internal state in female Drosophila

    Hui Chiu, Alice A Robie ... Catherine E Schretter

    While persistent aggressive states in females are promoted by select cell types with recurrent connections (aIPg, pC1d+e), additional data and models are needed to explain the maintenance of these states.
44. 1. Microbiology and Infectious Disease

    Mitochondrial protein FgDML1 regulates DON toxin biosynthesis and cyazofamid sensitivity in Fusarium graminearum by affecting mitochondrial homeostasis

    Chenguang Wang, Xuewei Mao ... Yiping Hou
45. 1. Developmental Biology
    2. Chromosomes and Gene Expression

    Massively parallel reporter assay for mapping gene-specific regulatory regions at single nucleotide resolution

    Alastair J Tulloch, Ryan N Delgado ... Constance L Cepko
46. 1. Developmental Biology
    2. Neuroscience

    The microtubule-binding protein EML3 is required for mammalian embryonic growth and cerebral cortical development; Eml3 null mice are a model of cobblestone brain malformation

    Isabelle Carrier, Eduardo Diez ... Roderick R McInnes
47. 1. Developmental Biology

    Meioc-Piwil1 complexes regulate rRNA transcription for differentiation of spermatogonial stem cells

    Toshihiro Kawasaki, Toshiya Nishimura ... Noriyoshi Sakai

    Analyses of zebrafish meioc mutants revealed that spermatogonial stem cells with low rRNA transcription caused by nucleolar Piwil1 require Meioc to keep Piwil1 in cytoplasm for the upregulation of rRNA transcription necessary for differentiation.
48. 1. Genetics and Genomics
    2. Neuroscience

    Rapid and inducible mislocalization of endogenous TDP43 in a novel human model of amyotrophic lateral sclerosis

    Johanna Ganssauge, Sophie Hawkins ... Akshay Bhinge

    A novel human iPSC-derived model induces mislocalization of endogenous TDP-43 without mutations or stress, recapitulating key ALS features including deficits in neuronal loss and morphology, splicing errors, and microRNA dysregulation.
49. 1. Cancer Biology
    2. Cell Biology

    Phosphodiesterase 1A physically interacts with YTHDF2 and reinforces the progression of non-small cell lung cancer

    Chong Zhang, Zuoyan Zhang ... Yangling Li

    Uncovering a novel PDE1A/YTHDF2/STAT3 pathway in non-small cell lung cancer (NSCLC) progression also provides therapeutic strategies for treating NSCLC patients with metastasis.
50. 1. Microbiology and Infectious Disease

    Identifying genetic variations in emm89 Streptococcus pyogenes associated with severe invasive infections

    Masayuki Ono, Masaya Yamaguchi ... Shigetada Kawabata

    Genetic analysis of Streptococcus pyogenes reveals multiple mutations, including a key change in the fhuB gene, that influence the bacteria’s ability to cause severe invasive infections.
51. 1. Developmental Biology
    2. Genetics and Genomics

    Coordinated Tbx3/Tbx5 transcriptional control of the adult ventricular conduction system

    Ozanna Burnicka-Turek, Katy A Trampel ... Ivan P Moskowitz

    Coordinated removal of Tbx3 and Tbx5 function alters the molecular features of the fast ventricular cardiac conduction system toward non-conduction working myocardium, illuminating transcriptional control of cardiac conduction system patterning.
52. 1. Developmental Biology

    Contraction-induced endocardial id2b plays a dual role in regulating myocardial contractility and valve formation

    Shuo Chen, Jinxiu Liang ... Peidong Han

    Endocardial id2b integrates biomechanical cues to orchestrate valve formation and myocardial maturation during cardiac development.
53. 1. Cell Biology

    Rho-ROCK liberates sequestered claudin for rapid de novo tight junction formation

    Yuma Cho, Akari Taniguchi ... Junichi Ikenouchi

    The Rho-ROCK–matriptase signaling axis promotes claudin release from EpCAM/TROP2 complexes, enabling tight junction reassembly during epithelial remodeling to preserve barrier integrity.
54. 1. Neuroscience

    The NIH BRAIN Initiative’s impacts in systems and computational neuroscience and team-scale research 2014–2023

    Farah Bader, Clayton Bingham ... James Gnadt

    The BRAIN Circuits Program of the NIH BRAIN Initiative has impacted how fundamental discovery in integrative systems neuroscience is investigated, commensurate with the complexity to address neurobehavioral and neurological dysfunctions.
55. 1. Neuroscience

    Social rank-order stability of mice revealed by a novel food competition paradigm in combination with available space competition paradigms

    Meiqiu Liu, Yue Chen, Rongqing Chen

    Social status of mice in an established colony is stably expressed in several types of competition paradigms, including food and space competitions.
56. 1. Neuroscience

    Formation of Task Representations and Replay in Mouse Medial Prefrontal Cortex

    Hamed Shabani, Hannah Muysers ... Christian Leibold
57. 1. Developmental Biology

    Multiple pathways prevent bi-parental mitochondria transmission in C. elegans

    Valentine Melin, Justine Cailloce ... Vincent Galy
58. 1. Genetics and Genomics
    2. Computational and Systems Biology

    JAX Animal Behavior System (JABS): A genetics informed, end-to-end advanced behavioral phenotyping platform for the laboratory mouse

    Anshul Choudhary, Brian Q Geuther ... Vivek Kumar
59. 1. Neuroscience

    Identification of novel human microcephaly-linked protein Mtss2 that mediates cortical progenitor cell division and corticogenesis through Nedd9-RhoA

    Aurelie Carabalona, Henna Kallo ... Claudio Rivera

    ABBA ensures proper cortical development by regulating radial glial division through RhoA activity at the cleavage furrow, and its mutation results in developmental abnormalities linked to microcephaly.
60. 1. Immunology and Inflammation

    A dual nature of γδ T cell immune memory responses

    Tsz Kin Suen, Burcu Al ... Katarzyna Placek

    Both adaptive and innate immune memory responses have been described in gamma delta T cells, yet the mechanisms, the ligands and the gamma delta T cell subsets generating memory responses have remain to be explored.
61. 1. Neuroscience

    Sexual failure decreases sweet taste perception in male Drosophila via dopaminergic signaling

    Gaohang Wang, Wei Qi ... Liming Wang

    Failure in sexual behaviors suppresses sweet taste perception of male fruit flies, by dampening dopaminergic signaling between mating-related neural circuits and peripheral gustatory pathways.
62. 1. Cell Biology

    Targeting the WSB2–NOXA axis in cancer cells for enhanced sensitivity to BCL-2 family protein inhibitors

    Dongyue Jiao, Kun Chang ... Chenji Wang

    Disrupting WSB2-mediated NOXA degradation sensitizes cancer cells to apoptosis and provides a new strategy to overcome resistance to BCL-2 inhibition.
63. 1. Immunology and Inflammation

    Bioengineering approaches to trained immunity: Physiologic targets and therapeutic strategies

    Hannah Riley Knight, Marie Kim ... Aaron Esser-Kahn

    Current approaches in bioengineering are synthesized and methods for their implementation are suggested for the induction and modulation of trained immunity in the treatment of human diseases.
64. 1. Cancer Biology

    Subtypes and proliferation patterns of small intestine neuroendocrine tumors revealed by single-cell RNA sequencing

    Einav Somech, Debdatta Halder ... Itay Tirosh

    SiNETs separate into two subtypes, both with low proliferation of neuroendocrine cells and higher proliferation of other cells.
65. 1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Stochastic cell-intrinsic stem cell decisions control colony growth in planarians

    Tamar Frankovits, Prakash Varkey Cherian ... Omri Wurtzel

    Stochastic intrinsic fate decisions by planarian stem cells drive clonal expansion and reveal a straightforward, feedback‐independent mechanism for robust cell identity selection.
66. 1. Developmental Biology
    2. Neuroscience

    Microtubule networks in zebrafish hair cells facilitate presynapse transport and fusion during development

    Saman Hussain, Katherine Pinter ... Katie S Kindt

    Formation of specialized ribbon synapses in sensory hair cells involves dynamic precursor movement, microtubule-guided transport, and precursor fusion, culminating in synapse assembly essential for hearing and balance.
67. 1. Neuroscience

    Synaptic Encoding of Time in Working Memory

    Gianluigi Mongillo, Misha Tsodyks
68. 1. Developmental Biology

    In vivo CRISPR screening identifies regulators of hyperplastic and hypertrophic adipose remodelling in zebrafish

    Rebecca Wafer, Panna Tandon, James EN Minchin
69. 1. Computational and Systems Biology

    OpenSpliceAI: An efficient, modular implementation of SpliceAI enabling easy retraining on non-human species

    Kuan-Hao Chao, Alan Mao ... Mihaela Pertea
70. 1. Cancer Biology

    Metastatic small cell lung cancer arises from TP53/RB1-deficient and MYC overproduction hESC-derived PNECs

    Huanhuan Joyce Chen, Eric E Gardner ... Harold Varmus

    A human pluripotent stem cell-based model demonstrates how TP53/RB1 loss and MYC overexpression drive aggressive, neuroendocrine small cell lung cancer progression and metastasis, enabling investigation of tumor heterogeneity and therapeutic response in a defined genetic context.
71. 1. Genetics and Genomics

    A genome-wide association study implicates the olfactory system in Drosophila melanogaster diapause-associated lifespan extension and fecundity

    Sreesankar Easwaran, Denise J Montell

    A genome-wide association study identifies 291 candidate genes for diapause and implicates olfactory pathway genes and cells in the regulation of this adaptive dormancy program in Drosophila.
72. 1. Computational and Systems Biology
    2. Physics of Living Systems

    Balancing reaction-diffusion network for cell polarization pattern with stability and asymmetry

    Yixuan Chen, Guoye Guan ... Chao Tang

    Reaction-diffusion network modeling unveils general design principles that both stabilize cell polarization patterns and enable tunable interface localization, reconciling extensive experimental observations and deepening the understanding of asymmetric cell division.
73. 1. Immunology and Inflammation
    2. Neuroscience

    Photoreceptor loss does not recruit neutrophils despite strong microglial activation

    Derek Power, Justin Elstrott, Jesse Schallek

    Systemic neutrophils do not respond to laser-induced photoreceptor damage despite the robust response from resident microglia.
74. 1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Cellular coordination underpins rapid reversals in gliding filamentous cyanobacteria and its loss results in plectonemes

    Jerko Rosko, Rebecca N Poon ... Orkun S Soyer

    Gliding multicellular cyanobacteria results from cellular coordination, the loss of which results in the collapse of orderly back-and-forth movement of filaments and in filament buckling.
75. 1. Neuroscience

    Increased listening effort and cochlear neural degeneration underlie speech-in-noise deficits in normal-hearing middle-aged adults

    Maggie E Zink, Leslie Zhen ... Aravindakshan Parthasarathy

    Cochlear neural degeneration in middle-aged adults with normal-hearing thresholds is associated with increased listening effort and behavioral deficits in challenging acoustic environments.
76. 1. Ecology
    2. Physics of Living Systems

    The dominant-egalitarian transition in species-rich communities

    David A Kessler, Nadav M Shnerb
77. 1. Biochemistry and Chemical Biology
    2. Neuroscience

    Modular DNA barcoding of nanobodies enables multiplexed in situ protein imaging and high-throughput biomolecule detection

    Shilin Zhong, Ruiyu Wang ... Minmin Luo

    A modular DNA barcoding strategy enables efficient multiplexed protein detection for both in situ imaging and high-throughput molecular diagnostics.
78. 1. Evolutionary Biology

    An initial report of circa 241,000- to 335,000-year-old rock engravings and their relation to Homo naledi in the Rising Star cave system, South Africa

    Lee R Berger, John Hawks ... Keneiloe Molopyane

    Engraved features found within the Dinaledi Subsystem are interpreted as being made by Homo naledi in the absence of evidence of other candidate makers.
79. 1. Neuroscience

    Alcohol Attenuates CRF-Induced Excitatory Effects from the Extended Amygdala to Dorsostriatal Cholinergic Interneurons

    Amanda Essoh, Himanshu Gangal ... Jun Wang
80. 1. Cancer Biology

    Design of combination therapeutics from protein response to drugs in ovarian cancer cells

    Alexandra Franz, Ciyue Shen ... Chris Sander
81. 1. Physics of Living Systems

    The evolution of interdisciplinarity and internationalization in scientific journals

    Huaxia Zhou, Luís A Nunes Amaral
82. 1. Neuroscience

    Single neurons detect spatiotemporal activity transitions through STP and EI imbalance

    Aditya Asopa, Upinder Singh Bhalla
83. 1. Cell Biology

    ATG2A engages RAB1A and ARFGAP1 positive membranes during autophagosome biogenesis

    Devin M Fuller, Yumei Wu ... Thomas J Melia
84. 1. Structural Biology and Molecular Biophysics

    Allosteric modulation of dimeric GPR3 by ligands in the dimerization interface

    Zeming Qiu, Wei Wang ... Sanduo Zheng
85. 1. Developmental Biology

    SLC35G3 is a UDP-N-acetylglucosamine transporter for sperm glycoprotein formation and underpins male fertility in mice

    Daisuke Mashiko, Shingo Tonai ... Masahito Ikawa
86. 1. Physics of Living Systems

    Quantifying Intracellular Mechanosensitive Response upon Spatially Defined Mechano-Chemical Triggering

    Elaheh Zare-Eelanjegh, Renard TM Lewis ... Tomaso Zambelli
87. 1. Neuroscience

    Neural circuit mechanisms for steering control in walking Drosophila

    Aleksandr Rayshubskiy, Stephen L Holtz ... Rachel Wilson

    Two descending neurons with distinct dynamics contribute to steering, including one influenced by both memory-guided and sensory-driven signals.
88. 1. Neuroscience

    Methamphetamine-induced adaptation of learning rate dynamics depend on baseline performance

    Hans Kirschner, Hanna M Molla ... Markus Ullsperger

    In individuals with moderately low baseline performance, methamphetamine reduces the tendency to misinterpret high outcome noise.
89. 1. Neuroscience

    Cntnap2 loss drives striatal neuron hyperexcitability and behavioral inflexibility

    Katherine R Cording, Emilie M Tu ... Helen S Bateup

    Deletion of the neurodevelopmental disorder gene Cntnap2 increases repetitive behaviors in mice and enhances the excitability of striatal direct pathway neurons through decreased potassium channel function.
90. 1. Neuroscience

    Ultrastructural sublaminar-specific diversity of excitatory synaptic boutons in layer 1 of the adult human temporal lobe neocortex

    Astrid Rollenhagen, Akram Sadeghi ... Joachim HR Lübke

    Quantitative 3D models of synaptic boutons were generated underlying important functional signal cascades of neocortical networks.
91. 1. Cancer Biology

    Δ133p53α and Δ160p53α isoforms of the tumor suppressor protein p53 exert dominant-negative effect primarily by co-aggregation

    Liuqun Zhao, Tanel Punga, Suparna Sanyal

    The N-terminally truncated Δ133p53α and Δ160p53α isoforms exert dominant-negative effects through co-aggregation with p53, disrupting its transcriptional activity and cellular distribution, thereby contributing to cancer development.
92. 1. Physics of Living Systems

    Q-learning with temporal memory to navigate turbulence

    Marco Rando, Martin James ... Agnese Seminara

    Animals may learn to locate preys effectively by memorizing short excerpts of their scent trace, which duration is dictated by the sparse nature of turbulent odor plumes.
93. 1. Immunology and Inflammation

    Layilin regulates Treg motility and suppressive capacity in skin

    Victoire Gouirand, Sean Clancy ... Michael D Rosenblum

    Regulatory T cell expression of layilin mediates adhesion in skin, which acts to attenuate their suppressive capacity.
94. 1. Cancer Biology
    2. Cell Biology

    A single cysteine residue in vimentin regulates long non-coding RNA XIST to suppress epithelial–mesenchymal transition and stemness in breast cancer

    Saima Usman, William Andrew Yeudall ... Ahmad Waseem

    Disruption of vimentin–actin interaction induces XIST expression and drives epithelial-to-mesenchymal transition and stem cell-like traits in breast cancer cells, enhancing oncogenic behaviour in nude mice independent of oestrogen.
95. 1. Neuroscience

    Dyadic Interaction Platform: A novel tool to study transparent social interactions

    Sebastian Isbaner, Raymundo Bäez-Mendoza ... Nivedita Mani
96. 1. Evolutionary Biology
    2. Genetics and Genomics

    Effective population size does not explain long-term variation in genome size and transposable element content in animals

    Alba Marino, Gautier Debaecker ... Benoit Nabholz

    A large-scale survey across animals reveals no general association between genome size expansion and the relaxation of natural selection.
97. 1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Improving SARS-CoV-2 variants monitoring in the absence of genomic surveillance capabilities: a serological study in Bolivian blood donors in October 2021 and June 2022

    Lucia Inchauste, Elif Nurtop ... Stéphane Priet

    A pioneering Bolivian seroepidemiological study employed innovative serological and neutralization assays as highly effective complements to genomic surveillance, delivering critical insights into SARS-CoV-2 variant circulation and informing public health strategies.
98. 1. Neuroscience

    Mediodorsal thalamic nucleus mediates resistance to ethanol through Ca_v3.1 T-type Ca²⁺ regulation of neural activity

    Charles-francois V Latchoumane, Joon-Hyuk Lee ... Hee-Sup Shin

    The firing mode of mediodorsal thalamic neurons may act as a central switching mechanism for the level of arousal and consciousness in natural sleep and induced ethanol hypnosis in mice.
99. 1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Correlates of protection against African swine fever virus identified by a systems immunology approach

    Kirill Lotonin, Francisco Brito ... Artur Summerfield
100. 1. Biochemistry and Chemical Biology

     Phenylhydrazone-based Endoplasmic Reticulum Proteostasis Regulator Compounds with Enhanced Biological Activity

     Gabriel M Kline, Lisa Boinon ... R Luke Wiseman
101. 1. Cell Biology
     2. Immunology and Inflammation

     G1 and G2 ApolipoproteinL1 modulate macrophage inflammation and lipid accumulation through the polyamine pathway

     Esther Liu, Matthew Wright ... Jennie Lin
102. 1. Neuroscience

     The influence of temporal context on vision over multiple time scales

     Kacie Lee, Reuben Rideaux
103. 1. Chromosomes and Gene Expression
     2. Genetics and Genomics

     A whole-organism landscape of X-inactivation in humans

     Bjorn Gylemo, Maike Bensberg, Colm E Nestor

     Genetic analyses of rare non-mosaic females define X-inactivation status for 380 genes and uncover widespread X-chromosome skewing in the general population, providing insights into sex-biased traits and X-linked disease expression.
104. 1. Neuroscience

     Integration of parallel pathways for flight control in a hawkmoth reflects prevalence and relevance of natural visual cues

     Ronja Bigge, Rebecca Grittner, Anna Lisa Stöckl

     In vision-based flight control of hummingbird hawkmoths, the visual field partitions by natural cue prevalence into an optic flow and dorsal directional pathway, which integrate according to their relevance for flight safety.
105. 1. Developmental Biology

     Pu.1/Spi1 dosage controls the turnover and maintenance of microglia in zebrafish and mammals

     Yi Wu, Weilin Guo ... Tao Yu

     Pu.1-P53 axis controls the turnover and maintenance of microglia by cell competition.
106. 1. Neuroscience

     POMC neurons control fertility through differential signaling of MC4R in kisspeptin neurons

     Rajae Talbi, Todd L Stincic ... Victor M Navarro

     Reproductive impairments in obese MC4R-deficient individuals are due to the absence of melanocortin signaling on Kiss1 neurons and not to their metabolic condition.
107. 1. Biochemistry and Chemical Biology
     2. Cell Biology

     Decoding protein phosphorylation during oocyte meiotic divisions using phosphoproteomics

     Leonid Peshkin, Enrico maria Daldello ... Catherine Jessus

     A comprehensive resource describes protein abundance and phosphorylation dynamics during Xenopus oocyte maturation, serving as an essential tool for investigating the molecular mechanisms driving meiotic progression.
108. 1. Structural Biology and Molecular Biophysics

     Interpretable protein-DNA interactions captured by structure-sequence optimization

     Yafan Zhang, Irene Silvernail ... Xingcheng Lin

     A predictive biophysical model that integrates protein-DNA structures and sequences to accurately determine genomic binding sites and affinities of DNA-binding proteins.
109. 1. Structural Biology and Molecular Biophysics

     Probing relaxed myosin states in hypertrophic cardiomyopathy by second harmonic-generation microscopy

     Giulia Arecchi, Marica Dente ... Chiara Tesi
110. 1. Cell Biology
     2. Physics of Living Systems

     Convergent Cellular Adaptation to Freeze-Thaw Stress via a Quiescence-like State in Yeast

     Charuhansini Tvishamayi, Farhan Ali ... Shashi Thutupalli
111. 1. Structural Biology and Molecular Biophysics

     SMC complex unidirectionally translocates DNA by coupling segment capture with an asymmetric kleisin path

     Masataka Yamauchi, Giovanni B Brandani ... Shoji Takada
112. 1. Developmental Biology

     SoxB1 family members inhibit Wnt signaling to promote maturation and deposition of stable neuromasts by the zebrafish Posterior Lateral Line primordium

     Greg Palardy, Kyeong-won Yoo ... Ajay B Chitnis
113. 1. Neuroscience

     Striatal Crosstalk Between Dopamine and Serotonin Systems

     Yu Liu, Juan Enriquez Traba, Christian Lüscher
114. 1. Neuroscience

     Heron, a Knowledge Graph editor for intuitive implementation of Python-based experimental pipelines

     George Dimitriadis, Ella Svahn ... Athena Akrami

     A Python-based, open source, GUI application for straightforward development and execution of scientific experiments over multiple machines.
115. 1. Neuroscience

     Single neurons and networks in the mouse claustrum integrate input from widespread cortical sources

     Andrew M Shelton, David K Oliver ... Adam Max Packer

     The claustrum integrates and redistributes sensory and frontal cortical inputs across distinct neural modules to enhance sensitivity to multimodal stimuli.
116. 1. Cell Biology
     2. Neuroscience

     The myeloid cell-driven transdifferentiation of endothelial cells into pericytes promotes the restoration of BBB function and brain self-repair after stroke

     Tingbo Li, Ling Yang ... Jie-Min Jia

     Changes in the pericyte pool after stroke affect the restoration of the blood-brain barrier function and brain self-repair, and offer a new approach to therapy.
117. 1. Structural Biology and Molecular Biophysics

     Cryo-EM structures of a pentameric ligand-gated ion channel in liposomes

     Vikram Dalal, Brandon K Tan ... Wayland WL Cheng

     The cryo-EM structures of a pentameric ligand-gated ion channel in liposomes, an environment that supports ion channel function, are different than structures in lipid nanodiscs.
118. 1. Medicine

     Therapeutic effects of PDGF-AB/BB against cellular senescence in human intervertebral disc

     Changli Zhang, Martha Elena Diaz-Hernandez ... Hicham Drissi

     PDGF mitigated cellular senescence in human intervertebral disc by modulating cell cycle, inflammation, and mitochondria function, offering a potential strategy for combating age-induced disc degeneration.
119. 1. Physics of Living Systems

     Physical constraints and biological regulations underlie universal osmoresponses

     Yiyang Ye, Qirun Wang, Jie Lin

     Theoretical modeling uncovers an unusual acceleration in microbial growth following osmotic shock, driven by the coordinated regulation of osmolyte production and cell-wall synthesis.
120. 1. Structural Biology and Molecular Biophysics

     Structure of human PIEZO1 and its slow-inactivating channelopathy mutants

     Yuanyue Shan, Xinyi Guo ... Duanqing Pei

     The architectures of human PIEZO1 and its slow-inactivating channelopathy mutants with or without its auxiliary subunit MDFIC reveal the inactivation mechanism of PIEZO channels.
121. 1. Ecology

     Developmental constraints mediate the summer solstice reversal of climate effects on European beech bud set

     Dominic Rebindaine, Thomas W Crowther ... Constantin M Zohner
122. 1. Genetics and Genomics
     2. Neuroscience

     C. elegans food choice exhibits effort discounting-like behavior

     Jonathan RM Millet, Serge Faumont ... Shawn R Lockery
123. 1. Genetics and Genomics

     Single-cell profiling of trabecular meshwork identifies mitochondrial dysfunction in a glaucoma model that is protected by vitamin B3 treatment

     Nicholas Tolman, Taibo Li ... Simon WM John
124. 1. Cell Biology
     2. Developmental Biology

     Inducible, virus-free direct lineage reprogramming enhances scalable generation of human inner ear hair cell-like cells

     Robert N Rainey, Sam D Houman ... Neil Segil
125. 1. Genetics and Genomics
     2. Medicine

     EPHA4 signaling dysregulation links abnormal locomotion and the development of idiopathic scoliosis

     Lianlei Wang, Xinyu Yang ... Nan Wu

     EPHA4 pathway dysfunction causes axon pathfinding defects, resulting in impaired coordinated left-right locomotion by disrupting neural patterning and the function of central pattern generators, thereby potentially leading to idiopathic scoliosis.
126. 1. Immunology and Inflammation
     2. Microbiology and Infectious Disease

     Malnutrition drives infection susceptibility and dysregulated myelopoiesis that persists after refeeding intervention

     Alisa Sukhina, Clemence Queriault ... Will Bailis

     Dysregulated myelopoiesis is identified as a driver of nutritionally acquired immunodeficiency that persists after refeeding and nutritional recovery, indicating exposure to food scarcity may be an immunologic risk factor.
127. 1. Computational and Systems Biology
     2. Physics of Living Systems

     A mathematical model for ketosis-prone diabetes suggests the existence of multiple pancreatic β-cell inactivation mechanisms

     Sean A Ridout, Priyathama Vellanki, Ilya Nemenman

     A simple mathematical model, incorporating reversible deactivation of β-cells, can potentially explain the rapid onset and remission of a diabetes subtype, ketosis-prone diabetes.
128. 1. Immunology and Inflammation

     Opposing regulation of TNF responses by IFN-γ and a PGE2-cAMP axis that is apparent in rheumatoid and immune checkpoint inhibitor-induced arthritis human IL-1β+ macrophages

     Upneet K Sokhi, Ruoxi Yuan ... Lionel B Ivashkiv

     Interferon-γ and prostaglandin E2 signaling oppose each other to determine the balance between two distinct TNF-induced inflammatory gene expression programs relevant for rheumatoid and immune checkpoint inhibitor-induced arthritis.
129. 1. Cell Biology
     2. Developmental Biology

     Female-germline specific protein Sakura interacts with Otu and is crucial for germline stem cell renewal and differentiation and oogenesis

     Azali Azlan, Li Zhu, Ryuya Fukunaga

     Sakura is expressed in female germlines, interacts with Otu, and is crucial for germline stem cell renewal and differentiation and oogenesis in Drosophila.
130. 1. Cell Biology
     2. Developmental Biology

     Human formin FHOD3-mediated actin elongation is required for sarcomere integrity in cardiomyocytes

     Dylan A Valencia, Angela N Koeberlein ... Margot E Quinlan

     Complementary biochemical and cell-biological approaches reveal that formin FHOD3-mediated actin elongation, rather than nucleation, is critical for maintaining cardiomyocyte sarcomeres.
131. 1. Ecology
     2. Evolutionary Biology

     Old age variably impacts chimpanzee engagement and efficiency in stone tool use

     Elliot Howard-Spink, Tetsuro Matsuzawa ... Dora Biro

     Long-term standardized data collection on wild western chimpanzees reveals late-life changes in stone tool use, and the extent of these changes varies between individuals.
132. 1. Neuroscience

     Differential roles of Na_V1.2 and Na_V1.6 in neocortical pyramidal cell excitability

     Joshua D Garcia, Chenyu Wang ... Kevin J Bender

     Na_V1.2 and Na_V1.6 have unique functional roles in neocortical pyramidal cells, regulating dendritic and axonal excitability, respectively.
133. 1. Neuroscience

     High-throughput synapse profiling reveals cell-type-specific spatial configurations in the fly brain

     Hongyang Wu, Yoh Maekawa ... Hiromu Tanimoto
134. 1. Neuroscience

     Hippocampal single-cell RNA Atlas of chronic methamphetamine abuse-induced cognitive decline in mice

     Hai Qiu, Xia Yue ... Dongfang Qiao
135. 1. Neuroscience

     Development of Auditory and Spontaneous Movement Responses to Music over the First Year of Life

     Trinh Nguyen, Félix Bigand ... Giacomo Novembre
136. 1. Neuroscience

     Unreliable homeostatic action potential broadening in cultured dissociated neurons

     Andreas Ritzau-Jost, Salil Rajayer ... Stefan Hallermann
137. 1. Cell Biology
     2. Neuroscience

     PD-linked LRRK2 G2019S mutation impairs astrocyte morphology and synapse maintenance via ERM hyperphosphorylation

     Shiyi Wang, Ryan Baumert ... Cagla Eroglu
138. 1. Neuroscience

     A cortical–hippocampal communication undergoes rebalancing after new learning

     Arron F Hall, Dong V Wang
139. 1. Chromosomes and Gene Expression
     2. Computational and Systems Biology

     Molecular Landscape of the Mouse Adrenal Gland and Adjacent Adipose by Spatial Transcriptomics

     Małgorzata Blatkiewicz, Szymon Hryhorowicz ... Marcin Rucinski
140. 1. Developmental Biology
     2. Computational and Systems Biology

     A quantitative pipeline for whole-mount deep imaging and analysis of multi-layered organoids across scales

     Alice Gros, Jules Vanaret ... Sham Tlili
141. 1. Neuroscience

     Humans underestimate their body mass in microgravity: evidence from reaching movements during spaceflight

     Zhaoran Zhang, Yu Tian ... Kunlin Wei
142. 1. Neuroscience

     Astrocytic modulation of population encoding in mouse visual cortex via GABA transporter 3 revealed by multiplexed CRISPR/Cas9 gene editing

     Jiho Park, Grayson O Sipe ... Mriganka Sur
143. 1. Developmental Biology
     2. Stem Cells and Regenerative Medicine

     PRDM16 functions as a co-repressor in the BMP pathway to suppress neural stem cell proliferation

     Li He, Jiayu Wen, Qi Dai

     PRDM16 directs BMP signaling outcomes by guiding SMAD complex genomic binding to repress neural stem cell proliferation and promote choroid plexus epithelial specification.
144. 1. Cancer Biology

     S100a4⁺ alveolar macrophages accelerate the progression of precancerous atypical adenomatous hyperplasia by promoting the angiogenic function regulated by fatty acid metabolism

     Hong Huang, Ying Yang ... Le Zhang

     S100a4⁺ alveolar macrophages facilitate angiogenesis through CPT1A-PPAR-γ-mediated fatty acid metabolism, thereby triggering atypical adenomatous hyperplasia.
145. 1. Biochemistry and Chemical Biology
     2. Structural Biology and Molecular Biophysics

     Harnessing AlphaFold to reveal hERG channel conformational state secrets

     Khoa Ngo, Pei-Chi Yang ... Igor Vorobyov

     Customized AlphaFold-based modeling of distinct functional states of the hERG channel, a major drug anti-target, significantly improves drug affinity predictions, enhancing cardiac safety screening for arrhythmia risk.
146. 1. Computational and Systems Biology
     2. Neuroscience

     Self-other generalisation shapes social interaction and is disrupted in borderline personality disorder

     Joseph M Barnby, Jen Nguyen ... London Personality and Mood Disorders Consortium

     Individuals with borderline personality disorder maintain rigid, distinct self-other representations, disrupting the bidirectional generalisation that underpins adaptive social learning and interpersonal trust.
147. 1. Neuroscience

     Normative evidence weighing and accumulation in correlated environments

     Nathan Tardiff, Jiwon Kang, Joshua I Gold

     Humans can appropriately use relationships among pieces of sensory evidence (pairwise correlations) to inform decisions, rather than relying only on the physical features of individual evidence samples.
148. 1. Physics of Living Systems
     2. Structural Biology and Molecular Biophysics

     Polyphosphate discriminates protein conformational ensembles more efficiently than DNA promoting diverse assembly and maturation behaviors

     Saloni Goyal, Divya Rajendran ... Athi N Naganathan

     Polyphosphate, a universal stress response regulator, binds distinctively to different starting ensembles of the same protein leading to either condensates or aggregates that in turn can solubilize or further aggregate, showcasing their ability to finely control the assembly process.
149. 1. Neuroscience

     The Self-Interest of Adolescents Overrules Cooperation in Social Dilemmas

     Xiaoyan Wu, Hongyu Fu ... Chao Liu
150. 1. Immunology and Inflammation
     2. Microbiology and Infectious Disease

     Glycosylated IgG antibodies accelerated the recovery of haemorrhagic fever with renal syndrome patients

     Chuansong Quan, Lu Wang ... Haifeng Hou
151. 1. Cell Biology

     The microbiome interacts with the circadian clock and dietary composition to regulate metabolite cycling in the Drosophila gut

     Yueliang Zhang, Sara B Noya ... Amita Sehgal

     The Drosophila microbiome regulates the cycling of gut metabolites in a circadian clock and diet-dependent manner.
152. 1. Neuroscience

     Acquisition of auditory discrimination mediated by different processes through two distinct circuits linked to the lateral striatum

     Susumu Setogawa, Takashi Okauchi ... Kazuto Kobayashi

     Two lateral striatal subregions integrate the acquisition of stimulus-based decision-making in spatiotemporally and functionally different manners, challenging the prior model through a dominance change from the associative to sensorimotor subregions.
153. 1. Neuroscience

     Ultraslow serotonin oscillations in the hippocampus delineate substates across NREM and waking

     Claire Cooper, Daniel Parthier ... Dietmar Schmitz

     The fine-tuning of mutual inhibition and disinhibition of sleep-regulating neurons and also the memory consolidation that occurs during NREM sleep are controlled by oscillations in serotonin levels.
154. 1. Biochemistry and Chemical Biology
     2. Structural Biology and Molecular Biophysics

     Mechanism of SK2 channel gating and its modulation by the bee toxin apamin and small molecules

     Samantha J Cassell, Weiyan Li ... Jonathan R Whicher
155. 1. Neuroscience

     The magnitude and time course of pre-saccadic foveal prediction depend on the conspicuity of the saccade target

     Lisa M Kroell, Martin Rolfs

     Foveal sensitivity to the features of an imminent saccade target increases with the target’s conspicuity, supporting foveal prediction as a viable mechanism for maintaining visual continuity in high-contrast, naturalistic environments.
156. 1. Microbiology and Infectious Disease

     Bacteriophage infection drives loss of β-lactam resistance in methicillin-resistant Staphylococcus aureus

     My Tran, Angel J Hernandez Viera ... Charlie Y Mo

     In methicillin-resistant Staphylococcus aureus, evolution of bacteriophage resistance causes trade-offs that re-sensitize the bacteriato β-lactam antibiotics.
157. 1. Developmental Biology

     NR2F2 is required in the embryonic testis for fetal Leydig cell development

     Aitana Perea-Gomez, Natividad Bellido Carreras ... Marie-Christine Chaboissier

     NR2F2 regulates fetal Leydig cell differentiation and steroidogenesis in mouse testes, providing mechanistic insight into testis development and the etiology of 46,XY differences in sex development.
158. 1. Microbiology and Infectious Disease
     2. Computational and Systems Biology

     REPOP: bacterial population quantification from plate counts

     Pedro Pessoa, Carol Lu ... Steve Pressé
159. 1. Structural Biology and Molecular Biophysics

     A high-resolution analysis of arrestin2 interactions responsible for CCR5 endocytosis

     Ivana Petrovic, Samit Desai ... Stephan Grzesiek
160. 1. Neuroscience

     Longitudinal tracking of neuronal activity from the same cells in the developing brain using Track2p

     Jure Majnik, Manon Mantez ... Rosa Cossart
161. 1. Microbiology and Infectious Disease

     Fast evolution of SOS-independent multi-drug resistance in bacteria

     Le Zhang, Yunpeng Guan ... Dayong Jin

     A single β-lactam exposure rapidly drives stable multidrug resistance in RecA-deficient bacteria through an SOS-independent mechanism involving oxidative stress-induced mutagenesis and antibiotic-driven selection.
162. 1. Neuroscience

     A temporally restricted function of the dopamine receptor Dop1R2 during memory formation

     Jenifer C Kaldun, Emanuele Calia ... Simon G Sprecher

     The dopamine receptor Dop1R2 plays a crucial role in the formation of longer-lasting memories, while it is dispensable for short-term memories.
163. 1. Evolutionary Biology
     2. Structural Biology and Molecular Biophysics

     Prebiotic gas flow environment enables isothermal nucleic acid replication

     Philipp Schwintek, Emre Eren ... Dieter Braun

     Exponential nucleic acid replication can occur isothermally in a prebiotically plausible setting that accumulates and simultaneously separates the strands of nucleic acids through evaporation-driven flows at the gas–water interface.
164. 1. Stem Cells and Regenerative Medicine

     CRISPR-edited DPSCs constitutively expressing BDNF enhance dentin regeneration in injured teeth

     Ji Hyun Kim, Muhammad Irfan ... Seung Chung

     Brain-derived neurotrophic factor/tropomyosin receptor kinase B signaling in promoting the differentiation and dentin-repair capacity of dental stem cells under inflammatory conditions offers a potential clinical strategy for repairing damaged teeth.
165. 1. Neuroscience

     Molecular characterization of gustatory second-order neurons reveals integrative mechanisms of gustatory and metabolic information

     Rubén Mollá-Albaladejo, Manuel Jiménez-Caballero, Juan Antonio Sanchez-Alcaniz

     Leucokinin neurons integrate sweet and bitter taste inputs with starvation signals to regulate feeding initiation, balancing nutrient intake against the risk of toxin ingestion.
166. 1. Neuroscience
     2. Computational and Systems Biology

     Reorganization of spinal neural connectivity following recovery after thoracic spinal cord injury: insights from computational modelling

     Natalia A Shevtsova, Andrew B Lockhart ... Simon M Danner
167. 1. Immunology and Inflammation

     Coenzyme A governs proinflammatory macrophage metabolism

     Greg. A Timblin, Kevin. M Tharp ... Valerie M Weaver
168. 1. Genetics and Genomics
     2. Computational and Systems Biology

     The impact of ambient contamination on demultiplexing methods for single-nucleus multiome experiments

     Terence Li, Marcus Alvarez ... Noah Zaitlen
169. 1. Microbiology and Infectious Disease

     An abundant merozoite surface protein of Plasmodium falciparum modulates susceptibility to inhibitory antibodies

     Isabelle G Henshall, Jill Chmielewski ... Danny W Wilson
170. 1. Genetics and Genomics
     2. Evolutionary Biology

     G protein-coupled receptor diversity and evolution in the closest living relatives of Metazoa

     Alain Garcia De Las Bayonas, Nicole King
171. 1. Computational and Systems Biology
     2. Neuroscience

     Homophilic wiring principles underpin neuronal network topology in vitro

     Danyal Akarca, Alexander WE Dunn ... Manuel Schröter
172. 1. Cell Biology

     Quantitative intra-Golgi transport and organization data suggest the stable compartment nature of the Golgi

     Hieng Chiong Tie, Haiyun Wang ... Lei Lu

     Quantitative measurements of intra-Golgi transport kinetics of diverse secretory cargos challenge the classic cisternal progression model and support the stable compartment model of the Golgi.
173. 1. Evolutionary Biology

     Diverse prey capture strategies in teleost larvae

     Duncan S Mearns, Sydney A Hunt ... Herwig Baier

     The evolution of hunting behavior in fish larvae has arrived at different, species-specific solutions, recombining a shared repertoire of locomotor and eye movement motifs.
174. 1. Microbiology and Infectious Disease

     Unraveling CRP/cAMP-mediated metabolic regulation in Escherichia coli persister cells

     Han G Ngo, Sayed Golam Mohiuddin ... Mehmet Orman

     CRP/cAMP plays a crucial role in the metabolic shift of Escherichia coli persisters from an anabolic state to oxidative phosphorylation, which is essential for their survival during antibiotic treatment.
175. 1. Immunology and Inflammation

     β-Glucan reprograms alveolar macrophages via neutrophil/IFNγ axis in a murine model of lung injury

     Renaud Prevel, Erwan Pernet ... Maziar Divangahi

     β-Glucan-mediated trained immunity activates alveolar macrophages which exacerbates acute lung injury induced by LPS.
176. 1. Neuroscience

     Humans adapt rationally to approximate estimates of uncertainty

     Erdem Pulcu, Michael Browning

     Humans estimate different forms of uncertainty during learning, but do so imprecisely, leading to the misattribution of random fluctuations as fundamental shifts.
177. 1. Microbiology and Infectious Disease

     Function and firing of the Streptomyces coelicolor contractile injection system requires the membrane protein CisA

     Bastien Casu, Joseph W Sallmen ... Susan Schlimpert

     CryoEM, genetic, and cell biological analyses reveal that the conserved membrane protein CisA mediates membrane recruitment of contractile injection systems Streptomyces coelicolor, enabling their activation under stress.
178. 1. Cell Biology

     Forward genetics in C. elegans reveals genetic adaptations to polyunsaturated fatty acid deficiency

     Delaney Kaper, Uroš Radović ... Marc Pilon

     Polyunsaturated fatty acids are not genetically replaceable in the nematode C. elegans and only mutations that help free ferrous ions can boost the activity of a poorly functioning desaturase enzyme.
179. 1. Cell Biology
     2. Physics of Living Systems

     Epithelial cell chirality emerges through the dynamic concentric pattern of actomyosin cytoskeleton

     Takaki Yamamoto, Tomoki Ishibashi ... Tatsuo Shibata

     Molecular chirality of actomyosin induces cell-scale chiral rotation without requiring a chiral arrangement of actomyosin filaments, revealing a key mechanism of cell chirality underlying left–right asymmetric tissue development.
180. 1. Neuroscience

     Neural Representation of Time across Complementary Reference Frames

     Yangwen Xu, Nicola Sartorato ... Roberto Bottini
181. 1. Medicine

     Noninvasive ultrasound targeted modulation of calcium influx in splenic immunocytes potentiates antineoplastic immunity attenuating hepatocellular carcinoma proliferation

     Wei Dong, Guihu Wang ... Zongfang Li
182. 1. Medicine
     2. Stem Cells and Regenerative Medicine

     Magnetically steered cell therapy for reduction of intraocular pressure as a treatment strategy for open-angle glaucoma

     M Reza Bahranifard, Jessica Chan ... C Ross Ethier

     Magnetically steered mesenchymal stem cells significantly lowered intraocular pressure for 9 months in mice, motivating the translation of this technology for the treatment of glaucoma.
183. 1. Cell Biology
     2. Medicine

     The ESCRT protein CHMP5 restricts bone formation by controlling endolysosome-mitochondrion-mediated cell senescence

     Fan Zhang, Yuan Wang ... Xianpeng Ge

     CHMP5 is crucial in preventing skeletal progenitor cell senescence and abnormal bone formation, and senolytic drugs represent potential therapeutic medicine for musculoskeletal abnormalities associated with a dysfunctional endolysosomal pathway.
184. 1. Cell Biology

     The molecular logic of Gtr1/2- and Pib2-dependent TORC1 regulation in budding yeast

     Jacob H Cecil, Cristina M Padilla ... Andrew P Capaldi

     Dual regulation of TORC1 by Gtr1/2 and Pib2 drives cells into three distinct signaling states, establishing a new paradigm for graded TORC1 signaling.
185. 1. Biochemistry and Chemical Biology

     Highly sensitive in vivo detection of dynamic changes in enkephalins following acute stress in mice

     Marwa O Mikati, Petra Erdmann-Gilmore ... Ream Al-Hasani

     An analytical approach increases spatiotemporal resolution, optimizes real-time, in vivo detection of Met- and Leu-enkephalin, and provides novel insight into the relationship between Met- and Leu-enkephalin following stress.
186. 1. Structural Biology and Molecular Biophysics

     The C-terminus of the multi-drug efflux pump EmrE prevents proton leak by gating transport

     Merissa Brousseau, Da Teng ... Katherine A Henzler-Wildman

     The C-terminal tail acts as a secondary gate to regulate substrate access into the primary binding site for transport across the membrane.
187. 1. Microbiology and Infectious Disease

     Heat stress induces phage tolerance in Enterobacteriaceae

     Fan Zhang, Hao-Ze Chen ... Jia-Feng Liu

     Bacterial persistence against phages enables survival under infection, and heat treatment enhances this tolerance, facilitating resistance evolution and influencing the effectiveness of phage therapy.
188. 1. Neuroscience

     Cestode larvae excite host neuronal circuits via glutamatergic signalling

     Anja de Lange, Hayley Tomes ... Joseph V Raimondo

     Parasitic tapeworm larvae release glutamate and other excitatory molecules that can directly excite brain neurons.
189. 1. Plant Biology

     Competence for transcellular infection in the root cortex involves a post-replicative, cell-cycle exit decision in Medicago truncatula

     Morgane Batzenschlager, Beatrice Lace ... Thomas Ott

     Imaging deep root tissues with a combination of cell-cycle reporters reveals that a cortical cell file traversed by symbiotic bacteria exhibits reduced proliferative potential and enters a prolonged G2 phase.
190. 1. Chromosomes and Gene Expression
     2. Developmental Biology

     Drosophila hamlet mediates epithelial tissue assembly of the reproductive system

     Huazhen Wang, Ludivine Bertonnier-Brouty ... Qi Dai

     Hamlet regulates heterotypic epithelial fusion by controlling spatial and temporal expression of known and novel epithelial regulators like Wnt and Tl pathway components, a mechanism potentially conserved through evolution.
191. 1. Neuroscience

     Multifaceted role of galanin in brain excitability

     Nicolas N Rieser, Milena Ronchetti ... Stephan CF Neuhauss

     The neuropeptide galanin modulates whole-brain activity and stress responses in zebrafish, revealing a complex, receptor-dependent role in seizure regulation with implications for epilepsy, and related neurological disorders.
192. 1. Neuroscience

     The interplay between homeostatic synaptic scaling and homeostatic structural plasticity maintains the robust firing rate of neural networks

     Han Lu, Sandra Diaz-Pier ... Andreas Vlachos

     A biphasic structural plasticity rule interacts with homeostatic synaptic scaling to maintain firing rate homeostasis in neural networks.
193. 1. Developmental Biology

     Glial betaPix is essential for blood vessel integrity in the zebrafish brain

     ShihChing Chiu, Qinchao Zhou ... Jing-Wei Xiong
194. 1. Microbiology and Infectious Disease

     The human cytomegalovirus-encoded pUS28 antagonizes CD4+ T cell recognition by targeting CIITA

     Fabienne Maassen, Vu Thuy Khanh Le-Trilling ... Mirko Trilling

     Through the destabilization of CIITA, the human cytomegalovirus-encoded protein pUS28 antagonizes the expression of the HLA-II molecules CD74/Ii, HLA-DR, HLA-DQ, HLA-DM, and HLA-DP, diminishing the activation of HCMV-specific CD4+ T cells and reducing their secretion of antiviral cytokines.
195. 1. Microbiology and Infectious Disease
     2. Physics of Living Systems

     Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides

     Ka Kiu Lee, Urszula Łapińska ... Stefano Pagliara

     Sub-populations of non growing bacteria survive treatment with antimicrobial peptides by mounting an efflux response.
196. 1. Neuroscience
     2. Physics of Living Systems

     Responses to membrane potential-modulating ionic solutions measured by magnetic resonance imaging of cultured cells and in vivo rat cortex

     Kyeongseon Min, Sungkwon Chung ... Jang-Yeon Park

     Magnetic resonance imaging, through its sensitivity to ionic environments that modulate membrane potential, enables noninvasive assessment of biological systems.
197. 1. Neuroscience
     2. Computational and Systems Biology

     Assemblies, synapse clustering, and network topology interact with plasticity to explain structure-function relationships of the cortical connectome

     András Ecker, Daniela Egas Santander ... Michael W Reimann

     A new framework for exploring the mechanisms underlying learning in cortical microcircuits is established.
198. 1. Immunology and Inflammation
     2. Medicine

     C-C chemokine receptor 4 deficiency exacerbates early atherosclerosis in mice

     Toru Tanaka, Naoto Sasaki ... Yoshiyuki Rikitake

     CCR4 expression in Tregs is critical for limiting proinflammatory Th1 cell-mediated immune responses and atherosclerosis by maintaining the suppressive and migratory functions of Tregs.
199. 1. Neuroscience

     Elucidating the selection mechanisms in context-dependent computation through low-rank neural network modeling

     Yiteng Zhang, Jianfeng Feng, Bin Min

     Mechanistic modeling with low-rank recurrent networks uncovers the relationship between network connectivity, neural dynamics, and selection modulation mechanisms in context-dependent computation.
200. 1. Neuroscience

     Intrinsic dynamic shapes responses to external stimulation in the human brain

     Maximilian Nentwich, Marcin Leszczynski ... Lucas C Parra

     A new computational model improves estimation of Granger connectivity by removing spurious effects of external inputs, and estimation of linear encoding models by removing spurious effects of recurrent connections.
201. 1. Developmental Biology

     Genetic compensation in podocalyxin-like mutants during zebrafish liver development

     Alexis N Ross, Natalie M Miscik ... Kimberley Jane Evason
202. 1. Structural Biology and Molecular Biophysics

     Insights from aquaporin structures into drug-resistant sleeping sickness

     Modestas Matusevicius, Robin A Corey ... Simone N Weyand
203. 1. Immunology and Inflammation

     Epidermal Resident Memory T Cell Fitness Requires Antigen Encounter in the Skin

     Eric S Weiss, Toshiro Hirai ... Daniel H Kaplan
204. 1. Neuroscience

     Hunger shifts attention and attribute weighting in dietary choice

     Jennifer March, Sebastian Gluth

     Extended multi-attribute attentional drift diffusion model reveals how attentional dynamics and weight shifts lead to less healthy decisions under hunger.
205. 1. Neuroscience

     Inference technique for the synaptic conductances in rhythmically active networks and application to respiratory central pattern generation circuits

     Yaroslav Molkov, Anke Borgmann ... Jeffrey Smith

     A robust method to infer excitatory and inhibitory synaptic conductances from neuronal recordings reveals functional circuit organization in rhythmic networks.
206. 1. Cell Biology
     2. Developmental Biology

     Planar cell polarity coordination in a cnidarian embryo provides clues to animal body axis evolution

     Julie Uveira, Antoine Donati ... Tsuyoshi Momose

     The jellyfish embryonic body axis is globally coordinated by conserved planar cell polarity (PCP) mechanisms and oriented by localised Wnt3 in two steps, highlighting PCP’s role in animal axis evolution.
207. 1. Structural Biology and Molecular Biophysics

     Structural insights into heterohexameric assembly of epilepsy-related ligand–receptor complex LGI1–ADAM22

     Takayuki Yamaguchi, Kei Okatsu ... Shuya Fukai

     Cryo-electron microscopy and high-speed atomic force microscopy analyses of an epilepsy-related ligand–receptor complex LGI1–ADAM22 reveal the three-dimensional structure and dynamics of the 3:3 heterohexameric assembly of LGI1–ADAM22.
208. 1. Biochemistry and Chemical Biology
     2. Developmental Biology

     Human eIF2A has a minimal role in translation initiation and in uORF-mediated translational control in HeLa cells

     Mykola Roiuk, Marilena Neff, Aurelio A Teleman

     Although eIF2A is thought to be a translation initiation factor, loss of eIF2A has no effect on cellular mRNA translation in either unstressed or stressed conditions.
209. 1. Biochemistry and Chemical Biology

     Exploiting functional regions in the viral RNA genome as druggable entities

     Dehua Luo, Yingge Zheng ... Dengguo Wei

     SHAPE-MaP reveals functional RNA structures in the porcine epidemic diarrhea virus genome, enabling targeted siRNA design and offering a promising strategy to inhibit viral replication.
210. 1. Cell Biology

     Negative regulation of miRNA sorting into EVs is mediated by the capacity of RBP PCBP2 to impair the SYNCRIP-dependent miRNA loading

     Francesco Marocco, Sabrina Garbo ... Marco Tripodi

     PCBP2 promotes miRNA cell retention by counteracting SYNCRIP-dependent miRNAs EV loading.
211. 1. Biochemistry and Chemical Biology

     Engineering NIR-Sighted Bacteria

     Stefanie SM Meier, Michael Hörzing ... Andreas Möglich
212. 1. Developmental Biology

     Cardiac fibroblasts regulate myocardium and coronary vasculature development in the murine heart via the collagen signaling pathway

     Yiting Deng, Yuanhang He ... Guang Li

     Cardiac fibroblasts play a critical role throughout the various phases of murine heart development ranging from the embryonic to the neonatal stage.
213. 1. Evolutionary Biology
     2. Immunology and Inflammation

     Current insights into insect immune memory

     Gabriela Krejčová, Adam Bajgar

     Insects possess a remarkable ability to develop innate immune memory, and the mechanisms underlying this process are becoming a central topic in innate immunity research.
214. 1. Computational and Systems Biology

     A neuromorphic model of active vision shows how spatiotemporal encoding in lobula neurons can aid pattern recognition in bees

     HaDi MaBouDi, Mark Roper ... James AR Marshall

     Active vision dynamically refines spatiotemporal neural representations, optimising visual processing through scanning behaviour and non-associative learning, providing insights into efficient sensory encoding in dynamic environments.