November 2025

Cover articles

    1. Computational and Systems Biology
    2. Neuroscience

    ITP signaling and homeostasis

    Jayati Gera, Marishia Agard ... Meet Zandawala
    1. Neuroscience

    No change for astroctyes

    Min Zhang, Naoto Kubota ... Sika Zheng
    1. Plant Biology

    Genetic pathways in brown algae

    Pélagie Ratchinski, Olivier Godfroy ... J Mark Cock
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease
    3. Medicine

    Focus Issue: Trained Immunity

    Edited by Satyajit Rath et al.

Highlights controls:

Research articles

    1. Medicine
    2. Epidemiology and Global Health

    Determining fragility and robustness to missing data in binary outcome meta-analyses, illustrated with conflicting associations between vitamin D and cancer mortality

    David Robert Grimes
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Microbiology and Infectious Disease
    2. Ecology

    Dark matter of an orchid: metagenome of the microbiome associated with the rhizosphere of Dactylorhiza traunsteineri

    Gabriel A Vignolle, Leopold Zehetner ... Julien Charest
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Developmental Biology

    E(spl)m4 Directly Antagonizes Traf4 to Inhibit JNK Signaling in Drosophila

    Katrin Strobel, Jennifer Falconi ... Alexandre Djiane
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    The Shigella flexneri effector IpaH1.4 facilitates RNF213 degradation and protects cytosolic bacteria against interferon-induced ubiquitylation

    Luz Saavedra-Sanchez, Mary S Dickinson ... Jorn Coers
    The enteric bacterial Shigella secretes a virulence factor that degrades the pivotal human defense protein RNF213, thereby protecting cytosolic bacteria from interferon-driven ubiquitylation and associated innate immunity.
    1. Cancer Biology
    2. Cell Biology

    Human RAP2A homolog of the Drosophila asymmetric cell division regulator Rap2l targets the stemness of glioblastoma stem cells

    Maribel Franco, Ricardo Gargini ... Ana Carmena
    Restitution of RAP2A, human homolog of Drosophila asymmetric cell division regulator Rap2l, in glioblastoma neurosphere cultures targets the stemness of glioblastoma stem cells and could contribute to reduce glioblastoma expansion.
    1. Neuroscience

    Functional and molecular insights into muscle proprioceptors

    Francois Lallemend, Prach Techameena, Saida Hadjab
    The emerging taxonomy of proprioceptive neuron subtypes provides a framework for dissecting the cellular logic of sensorimotor control.
    1. Neuroscience

    Center-surround inhibition in expectation and its underlying computational and artificial neural network models

    Ling Huang, Shiqi Shen ... Xilin Zhang
    Expectation optimizes perception through center-surround inhibition, enhancing expected representations while suppressing similar, irrelevant ones.
    1. Medicine
    2. Immunology and Inflammation

    Hyperactivated Glycolysis Drives Spatially-Patterned Kupffer Cell Depletion in MASLD

    Jia He, Ran Li ... Zhao Shan
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Cancer Biology

    Candida albicans drives colorectal cancer progression by inducing hypoxia signaling

    Wanqiu Wang, Mengqi Yang ... Kun Sun
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Neuroscience

    An interneuronal CRH and CRHBP circuit stabilizes birdsong performance

    Bradley M Colquitt, Michael S Brainard
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Neuroscience

    Prosapip1 (encoded by the Lzts3 gene) in the dorsal hippocampus mediates synaptic protein composition, long-term potentiation, and spatial memory

    Zachary W Hoisington, Himanshu Gangal ... Dorit Ron
    Novel function of Prosapip1, a scaffolding protein highly expressed in the hippocampus, in maintaining postsynaptic density integrity and plays a vital role in synaptic plasticity, learning, and memory.
    1. Cell Biology

    Specific proteolysis mediated by a p97-directed proteolysis-targeting chimera (PROTAC)

    Constanza Salinas-Rebolledo, Javier Blesa ... Alejandro Rojas-Fernandez
    1. Cell Biology

    SMC5/6-mediated plasmid silencing is directed by SIMC1–SLF2 and antagonized by the SV40 large T antigen

    Martina Oravcová, Minghua Nie ... Michael N Boddy
    Distinct SMC5/6 subcomplexes mediate the transcriptional silencing of circular extrachromosomal DNA (SIMC1–SLF2) and repair of chromosomal DNA lesions (SLF1–SLF2), thus enabling exploration of SMC5/6 functions in innate immunity and cancer.
    1. Cell Biology

    The RAB27A effector SYTL5 regulates mitophagy and mitochondrial metabolism

    Ana Lapão, Lauren Sophie Johnson ... Anne Simonsen
    RAB27A-dependent mitochondrial recruitment of SYTL5 promotes mitophagy and mitochondrial bioenergetics upon hypoxia.
    1. Neuroscience

    Ubiquitous predictive processing in the spectral domain of sensory cortex

    Eli Sennesh, Jacob A Westerberg ... Andre Bastos
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Computational and Systems Biology

    TSvelo: Comprehensive RNA velocity by modeling the cascade of gene regulation, transcription and splicing

    Jiachen Li, Zhe Wang ... Ye Yuan
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Comprehensive characterization of human color discrimination thresholds

    Fangfang Hong, Ruby Bouhassira ... David H Brainard
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Biochemistry and Chemical Biology

    In search of nonlipogenic ABCA1 inducers (NLAI): precision coregulator TR-FRET identifies diverse signatures for LXR ligands

    Megan S Laham, Martha Ackerman-Berrier ... Gregory RJ Thatcher
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Microbiology and Infectious Disease
    2. Plant Biology

    P-body formation is required for yeast proliferation in the phyllosphere

    Fuka Sekioka, Kosuke Shiraishi ... Hiroya Yurimoto
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Developmental Biology

    From salience to semantics: multilevel hierarchical contingencies organise parent-infant joint attention

    Pierre Labendzki, Marta Perapoch Amadó ... Sam V Wass
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    High-throughput development and characterization of new functional nanobodies for gene regulation and epigenetic control in human cells

    Jun Wan, Abby R Thurm ... Lacramioara Bintu
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Endogenous corazonin signaling modulates the post-mating switch in behavior and physiology in females of the brown planthopper and Drosophila

    Ning Zhang, Shao-Cong Su ... Shun-Fan Wu
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Ecology

    Geomagnetic and visual cues guide seasonal migratory orientation in the nocturnal fall armyworm, the world’s most invasive insect

    Yi-Bo Ma, Gui-Jun Wan ... Gao Hu
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Neuroscience

    Sensitivity of the human temporal voice areas to nonhuman primate vocalizations

    Leonardo Ceravolo, Coralie Debracque ... Didier Grandjean
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Computational and Systems Biology

    Learning sequence-function relationships with scalable, interpretable Gaussian processes

    Juannan Zhou, Carlos Martí-Gómez ... David M McCandlish
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Increased layer 5 Martinotti cell excitation reduces pyramidal cell population plasticity and improves learned motor execution

    Thawann Malfatti, Anna Velica ... Klas Kullander
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Microbiology and Infectious Disease

    Three pathways feed the folate-dependent one carbon pool for growth and virulence of Listeria monocytogenes

    Sandra Freier, Sarah Frentzel ... Sven Halbedel
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Early readers know letter shape without knowing letter names

    Jhilik Das, Sonali Nag ... SP Arun
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Natural xanthones as α-Mangostin induce vasorelaxation via binding to key gating residues in the S6 domain of BK channels

    Sönke Cordeiro, Robert Patejdl ... Marianne Musinszki
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Genetics and Genomics
    2. Neuroscience

    Avoidance of hydrogen sulfide is modulated by external and internal states in Caenorhabditis elegans

    Longjun Pu, Lina Zhao ... Changchun Chen
    Mitochondrial remodeling, ROS-dependent signaling, and diverse environmental and physiological cues underlie the initiation and persistence of locomotory activity of C. elegans in toxic H2S.
    1. Evolutionary Biology

    Evolution of gene expression in seasonal environments

    Shuichi N Kudo, Yuka Ikezaki ... Akiko Satake
    A comparative analysis of genome-wide seasonal gene expression dynamics across four forest tree species revealed that a shared 'molecular calendar' emerges in winter, constraining gene expression evolution and potentially limiting temporal niche partitioning and species divergence in seasonal environments.
    1. Chromosomes and Gene Expression

    Decapping activators Edc3 and Scd6 act redundantly with Dhh1 in post-transcriptional repression of starvation-induced pathways

    Rakesh Kumar, Fan Zhang ... Alan G Hinnebusch
    Multi-omics analyses reveal redundant functions of yeast mRNA decapping activators Scd6 and Edc3 in facilitating recruitment of helicase Dhh1 and accelerating degradation of transcripts required for respiration in glucose-replete cells.
    1. Neuroscience

    A meta-analysis suggests that TMS targeting the hippocampal network selectively improves episodic memory

    Elena Badillo Goicoechea, Phillip F Agres ... Joel L Voss
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Convincing
    1. Neuroscience

    Visuomotor mismatch EEG responses in occipital cortex of freely moving human subjects

    Magdalena Solyga, Marek Zelechowski, Georg B Keller
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience
    2. Computational and Systems Biology

    Alpha rhythm subharmonics underlie responsiveness to theta burst stimulation via calcium metaplasticity

    Kevin Kadak, Davide Momi ... John D Griffiths
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Neuroscience

    Generation of biophysical neuron model parameters from recorded electrophysiological responses

    Jimin Kim, Minxian Peng ... Eli Shlizerman
    A deep generative approach learns the translation from neurons’ electrophysiological recordings to the biophysical parameters of neuron models, assisting in the development of a detailed nervous system model.
    1. Microbiology and Infectious Disease

    RBMX2 links Mycobacterium bovis infection to epithelial–mesenchymal transition and lung cancer progression

    Chao Wang, Yongchong Peng ... Yingyu Chen
    Integrative analyses uncover RBMX2 as a pivotal mediator that bridges Mycobacterium bovis infection to epithelial–mesenchymal transition and tumor progression in the lung.
    1. Genetics and Genomics

    Non-visual light modulates behavioral memory and gene expression in C. elegans

    Zhijian Ji, Bingying Wang ... Dengke K Ma
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    ATP-independent phosphate recycling on AGC kinase activation loops induced by alkali metal ions

    Koji Kubouchi, Hideyuki Mukai
    Not revised
    Reviewed Preprint v1
    • Incomplete
    1. Genetics and Genomics

    CNN-based learning of single-cell transcriptomes reveals a blood-detectable multi-cancer signature of brain metastasis

    Ryan Lusby, Debojyoti Chowdhury ... Vijay K Tiwari
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Developmental prosopagnosics have normal spatial integration in posterior ventral face-selective regions

    Daniel A Stehr, Yiyuan Zhang ... Bradley Duchaine
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Neuroscience

    Differential locus coeruleus–hippocampus interactions during offline states

    Mingyu Yang, Oxana Eschenko
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Incomplete
    1. Neuroscience

    Overcoming distortion in multidimensional predictive representation

    Euan Prentis, Akram Bakkour
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Redirection of SARS-CoV-2 to phagocytes by intranasal sACE2-Fc as a universal decoy confers complete prophylactic protection

    Jingyi Wang, Jiangchuan Li ... Bo Feng
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Neuroscience

    Functional characterization of neuropeptides that act as ligands for both calcitonin-type and pigment-dispersing factor-type receptors in a deuterostome

    Xiao Cong, Huachen Liu ... Muyan Chen
    Cell-line experiments and in vivo functional experiments provide the evidence that CT-type peptides can act as ligands for both CTR/CLR-type and PDF-type receptors in a deuterostome.
    1. Developmental Biology
    2. Evolutionary Biology

    HoxB-derived hoxba and hoxbb clusters are essential for the anterior–posterior positioning of zebrafish pectoral fins

    Morimichi Kikuchi, Renka Fujii ... Akinori Kawamura
    HoxB-dependent anterior–posterior patterning and the evolutionary origin of pectoral fins.
    1. Neuroscience

    Peripheral glia and neurons jointly regulate activity-induced synaptic remodeling at the Drosophila neuromuscular junction

    Yen-Ching Chang, Yi-Jheng Peng ... Karen T Chang
    Peripheral glia regulate synaptic remodeling at the Drosophila neuromuscular junction by balancing neuron-derived signals and controlling ambient glutamate levels, thereby revealing distinct glial mechanisms in activity-dependent synaptic plasticity.
    1. Neuroscience

    Progressive remote memory decline coincides with parvalbumin interneuron hyperexcitability and enhanced inhibition of cortical engram cells in a mouse model of Alzheimer’s disease

    Julia J van Adrichem, Rolinka J van der Loo ... Ronald E van Kesteren
    Remote memories in Alzheimer’s disease are impaired through loss of inhibitory control over cortical engram neurons by hyperexcitable parvalbumin interneurons.
    1. Neuroscience

    Hierarchical Bayesian modeling of multiregion brain cell count data

    Sydney Dimmock, Benjamin MS Exley ... Cian O'Donnell
    Bayesian hierarchical models offer powerful statistical tools for neuroscientists to analyze whole-brain cell count data, as demonstrated here using two example datasets from different laboratories.
    1. Neuroscience

    PTBP1 depletion in mature astrocytes reveals distinct splicing alterations without neuronal features

    Min Zhang, Naoto Kubota ... Sika Zheng
    PTBP1 loss in mature astrocytes causes unique astrocytic splicing changes, not neuronal-like, contrasting its role in other non-neuronal cells and indicating PTBP1 depletion alone is ineffective to drive adult-astrocyte-to-neuron conversion.
    1. Cell Biology
    2. Neuroscience

    Endosome-associated Rab GTPases control distinct aspects of neural circuit assembly

    Katherine X Dong, Hui Ji ... Colleen N McLaughlin
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Chromosomes and Gene Expression

    The chromatin remodeller CHD4 regulates transcription factor binding to both prevent activation of silent enhancers and maintain active regulatory elements

    Andria Koulle, Oluwaseun Ogundele ... Brian Hendrich
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Neuroscience

    Spatially heterogeneous inhibition projects sequential activity onto unique neural subspaces

    Andrew B Lehr, Arvind Kumar, Christian Tetzlaff
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Neuroscience

    Synaptic density and relative connectivity conservation maintain circuit stability across development

    Ingo Fritz, Feiyu Wang ... André Ferreira Castro
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Cholecystokinin modulates age-dependent thalamocortical neuroplasticity

    Xiao Li, Jingyu Feng ... Jufang He
    Cholecystokinin gates age-dependent auditory thalamocortical plasticity and, upon supplementation, reverses age-related plasticity decline and improves frequency discrimination.
    1. Neuroscience

    A stochastic RNA editing process targets a select number of sites in individual Drosophila glutamatergic motoneurons

    Andrés B Crane, Michiko O Inouye ... J Troy Littleton
    Patch-seq RNA profiling defines the overall RNA editing landscape and single neuron editing rules for individual genetically defined Drosophila larval motoneurons.
    1. Computational and Systems Biology

    Martinize2 and Vermouth provide a unified framework for molecular topology generation

    Peter C Kroon, Fabian Grünewald ... Siewert J Marrink
    Enabling high-throughput simulations of proteins within the Martini framework.
    1. Chromosomes and Gene Expression

    UV irradiation alters TFAM binding to mitochondrial DNA

    Dillon E King, Emily E Beard ... Joel N Meyer
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Inadequate
    1. Developmental Biology

    Bidirectional translocation of actomyosin drives epithelial invagination in ascidian siphon tube morphogenesis

    Jinghan Qiao, Pengyu Yu ... Bo Dong
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    • Incomplete
    1. Cell Biology

    Analysis of cancer mutations introduced into the Drosophila Notch Negative Regulatory Region uncovers a diversity of regulatory outcomes

    Hideyuki Shimizu, Martin Baron
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Structural Biology and Molecular Biophysics

    Conduction pathway for potassium through the Escherichia coli pump KdpFABC

    Adel Hussein, Xihui Zhang ... David L Stokes
    The path of potassium through an ATP-dependent membrane pump is elucidated with a high-resolution structure within a lipid bilayer together with mutational analysis at key points along this pathway.
    1. Physics of Living Systems

    Quantifying the shape of cells, from Minkowski tensors to p-atic orders

    Lea Happel, Griseldis Oberschelp ... Axel Voigt
    Only rigorous mathematical tools to quantify the shape of cells can guarantee reliable results in coarse-grained descriptions of tissue dynamics.
    1. Developmental Biology

    Comprehensive profiling of migratory primordial germ cells reveals niche-specific differences in non-canonical Wnt and Nodal-Lefty signaling in anterior vs posterior migrants

    Rebecca Garrett Jaszczak, Jay W Zussman ... Diana J Laird
    A temporal and positional atlas of mouse primordial germ cell (PGC) migration reveals dynamic gene expression and somatic cell interactions that suggest how changing migratory niches regulate PGC development.
    1. Microbiology and Infectious Disease

    The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2

    Rahul K Suryawanshi, Priyadarshini Jaishankar ... James S Fraser
    The development of new small molecules demonstrates how pharmacologic inhibition of the coronavirus macrodomain restores innate immunity, leading to reduced viral replication and improved outcomes in severe infection.
    1. Biochemistry and Chemical Biology

    MCAK recognizes the nucleotide-dependent feature at growing microtubule ends

    Wei Chen, Yin-Long Song ... Xin Liang
    A key finding is that MCAK binds to the proximal region of GTP cap where GDP‧Pi-tubulins accumulate, in addition to curved protofilaments at the distalmost tip.
    1. Plant Biology

    Life-cycle-related gene expression patterns in the brown algae

    Pélagie Ratchinski, Olivier Godfroy ... J Mark Cock
    Life-cycle- and development-related patterns of gene expression are conserved in diverse brown algae.
    1. Neuroscience

    Traveling waves across scales: Different mechanisms but same canonical computation?

    Laura Dugué, Frédéric Chavane
    The review proposes a novel mechanistic distinction between first- and second-order traveling waves that subserves a same canonical computation by ordering neuronal processing to impose a computational syntax.
    1. Chromosomes and Gene Expression

    Interplay between cohesin and TORC1 links chromosome segregation and gene expression to environmental changes

    Dorian Besson, Sabine Vaur ... Jean-Paul Javerzat
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Kinesin-1 conformational dynamics are controlled by a cargo-sensitive TPR switch

    Shivam Shukla, Jessica A Cross ... Mark P Dodding
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Role of tankyrase scaffolding in the β-catenin destruction complex and WNT signaling

    Qian Wang, Liping Li ... Chuo Chen
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Investigation of All Disease-Relevant Lysine Acetylation Sites in α-Synuclein Enabled by Non-canonical Amino Acid Mutagenesis

    Marie Shimogawa, Ming-Hao Li ... E James Petersson
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Developmental Biology

    HSD17B7 is required for Auditory Function by Regulating Cholesterol Synthesis in Sensory Hair Cells

    Yuqian Shen, Ziyang Wang ... Dong Liu
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Genetics and Genomics

    Genomic privacy risks in GWAS summary statistics

    Ao Lan, Yudi Pawitan, Xia Shen
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Structural Biology and Molecular Biophysics

    Multi-barrier unfolding of the double-knotted protein, TrmD–Tm1570, revealed by single-molecule force spectroscopy and molecular dynamics

    Fernando Bruno da Silva, Szymon Niewieczerzal ... Joanna I Sulkowska
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Cell Biology

    Roles of G-protein coupled receptors and mechanosensitive ion channels in pressure-induced chronotropy of lymphatic vessels

    Michael J Davis, Hae Jin Kim ... Scott D Zawieja
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    • Incomplete
    1. Neuroscience

    A deep learning approach for the analysis of birdsong

    Therese MI Koch, Ethan S Marks, Todd F Roberts
    An open-source deep learning toolkit performs accurate annotation and similarity scoring of zebra finch song, along with comprehensive feature extraction, enabling consistent, interpretable comparisons of vocal phenotypes across research groups.
    1. Neuroscience

    Mother-child dyadic interactions shape the developing social brain and Theory of Mind in young children

    Lei Li, Jinming Xiao ... Xujun Duan
    Children’s social cognitive development emerges from the dynamic interplay of neural maturation, parental caregiving, and dyadic brain-to-brain synchrony.
    1. Genetics and Genomics

    Phenotypic impact of individual conserved neuronal microexons and their master regulators in zebrafish

    Laura Lopez-Blanch, Cristina Rodríguez-Marin ... Manuel Irimia
    A multi-level assessment of the relevance of 18 highly conserved neural zebrafish microexons showed that individual deletions of most microexons did not exhibit strong phenotypes, likely because of compensatory changes.
    1. Cell Biology
    2. Computational and Systems Biology

    Extrusion-modulated DnaA activity oscillations coordinate DNA replication with biomass growth

    Dengjin Li, Hai Zheng ... Chenli Liu
    Chromosome-driven DnaA activity oscillations, modulated by DNA-binding proteins, enable bacteria to coordinate DNA replication with biomass growth independently of transcriptional regulation.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Smed-pou4-2 regulates mechanosensory neuron regeneration and function in planarians

    Ryan A McCubbin, Mohammad A Auwal ... Ricardo M Zayas
    A conserved POU4-dependent developmental program underlies mechanosensory neuron regeneration in adult planarians.
    1. Developmental Biology
    2. Neuroscience

    Removal of developmentally regulated microexons has a minimal impact on larval zebrafish brain morphology and function

    Caleb CS Calhoun, Mary ES Capps ... Summer B Thyme
    Sensitive brain activity mapping and behavioral profiling reveal most microexons are dispensable for early brain development but highlight a small subset with intriguing neural phenotypes for future study.
    Version of Record
    Short Report
    • Important
    • Solid
    1. Plant Biology

    Fifteenth century CE Bolivian maize reveals genetic affinities with ancient Peruvian maize

    Huan Chen, Amy Baetsen-Young ... Gabriel Wrobel
    Genomic evidence from 15th-century Bolivian maize reveals similarity to Central Andean maize from Peru, and pre-Inca and Inca-era breeding that enhanced maize development through selection within Andean agricultural networks.
    1. Developmental Biology

    Mouse germline cysts contain a fusome that mediates oocyte development

    Madhulika Pathak, Allan C Spradling
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Local, calcium- and reward-based synaptic learning rule that enhances dendritic nonlinearities can solve the nonlinear feature binding problem

    Zahra Khodadadi, Daniel Trpevski ... Jeanette Hellgren Kotaleski
    Biophysically detailed modeling predicts that a biologically plausible synaptic plasticity rule, gated by calcium and dopamine, enables single neurons to solve nonlinear binding tasks by exploiting dendritic nonlinearities.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    The role of co-infection in the pathogenesis of acute SARS-CoV-2 infection and development of post-acute sequelae: A perspective

    Timothy J Henrich, Christopher P Montgomery ... Maria Laura Gennaro
    Unraveling mechanisms underlying post-acute SARS-CoV-2 sequelae (long COVID) and finding therapeutic solutions require a full understanding of the causative role of SARS-CoV-2 persistence and/or infection with other microorganisms, which may be pre-existing, concurrent, or subsequent to acute COVID-19.
    1. Medicine

    The denitrosylase SCoR2 controls cardioprotective metabolic reprogramming

    Zachary W Grimmett, Rongli Zhang ... Jonathan S Stamler
    Mice lacking the denitrosylase enzyme SCoR2 demonstrate robust cardioprotection resulting from coordinate reprogramming of multiple metabolic pathways.
    1. Cancer Biology

    Causal associations between human plasma proteins and prostate cancer identified by proteome-wide Mendelian randomization

    Lin Chen, Yanlun Gu ... Xiaocong Pang
    The identification of 20 causal plasma proteins for prostate cancer represents a critical step toward addressing the need for improved diagnostic specificity and reveals promising new targets for therapeutic intervention.
    1. Microbiology and Infectious Disease

    Nanoscopy Reveals Heparan Sulfate Clusters as Docking Sites for SARS-CoV-2 Attachment and Entry

    Sue Han, Xin Wang ... Ling-Gang Wu
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Biochemistry and Chemical Biology

    Profiling of terminating ribosomes reveals translational control at stop codons

    Longfei Jia, Yuanhui Mao ... Shu-Bing Qian
    Not revised
    Reviewed Preprint v1
    • Useful
    • Convincing
    • Inadequate
    1. Immunology and Inflammation

    Direct contact between iPSC-derived macrophages and hepatocytes drives reciprocal acquisition of Kupffer cell identity and hepatocyte maturation

    Christopher Zhe Wei Lee, Farah Tasnim ... Florent Ginhoux
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Convincing
    1. Microbiology and Infectious Disease

    Apparent cooperativity between human CMV virions introduces errors in conventional methods of calculating multiplicity of infection

    Christopher Peterson, Joshua Miller ... Vitaly V Ganusov
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Immunology and Inflammation

    Epigenetic Adaptation Drives Monocyte Differentiation into Microglia-Like Cells Upon Engraftment into the Central Nervous System

    Jie Liu, Fengyang Lei ... Eleftherios I Paschalis
    Not revised
    Reviewed Preprint v1
    • Useful
    • Inadequate
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Innate immune memory: The evolving role of macrophages in therapy

    Payal Damani-Yokota, Kamal Mohan Khanna
    Epigenetic and metabolic programming of innate immune cells shapes host defense and disease susceptibility.
    1. Cell Biology

    Membrane potential modulates ERK activity and cell proliferation in human cells

    Mari Sasaki, Masanobu Nakahara ... Fumihito Ono
    Membrane depolarization promotes extracellular signal-regulated kinase activation and cell proliferation via phosphatidylserine dynamics.
    1. Biochemistry and Chemical Biology

    Growth inhibitory factor/metallothionein-3 is a sulfane sulfur-binding protein

    Yasuhiro Shinkai, Yunjie Ding ... Yoshito Kumagai
    The hold-and-release regulation of zinc by GIF/MT-3 is mediated by sulfane sulfur through a redox-dependent switching mechanism.
    1. Neuroscience

    Elevated DNA damage without signs of aging in the short-sleeping Mexican cavefish

    Evan Lloyd, Fanning Xia ... Alex C Keene
    Cavefish exhibit resilience to chronic sleep loss and tolerate elevated DNA damage and reduced DNA repair responses without compromising healthspan or longevity.
    1. Neuroscience

    Relationship between cognitive abilities and mental health as represented by cognitive abilities at the neural and genetic levels of analysis

    Yue Wang, Richard Anney, Narun Pat
    Multimodal neuroimaging explained 66% of the cognitive–mental health link in children, outperforming polygenic scores (21%), and accounted for 58% of the environmental contribution to this relationship.
    1. Neuroscience

    Excitatory cholecystokinin neurons in CA3 area regulate the navigation learning and neuroplasticity

    Fengwen Huang, Abdul Baset, Stephen Temitayo Bello
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Readout and delayed transmission of initial afferent V1 activity in decisions about stimulus contrast

    Kieran S Mohr, Simon P Kelly
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Hugin-AstA circuitry is a novel central energy sensor that directly regulates sweet sensation in Drosophila and mouse

    Wusa Qin, Tingting Song ... Rui Huang
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Long-range inhibitory axons from medial entorhinal cortex target lateral entorhinal neurons projecting to the hippocampal formation

    Eirik S Nilssen, Bente Jacobsen ... Menno P Witter
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Genetics and Genomics
    2. Neuroscience

    Acute opioid responses are modulated by dynamic interactions of Oprm1 and Fgf12

    Paige M Lemen, Yanning Zuo ... Hao Chen
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Neuroscience

    Progressive postnatal hearing development limits early parent-offspring vocal communication in the zebra finch

    Tommi Anttonen, Jakob Christensen-Dalsgaard, Coen PH Elemans
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Repeated vaccination with homologous influenza hemagglutinin broadens human antibody responses to unmatched flu viruses

    Yixiang Deng, Melbourne Tang ... Daniel Lingwood
    Classical antibody boosting effects during vaccination are accompanied by natural broadening mechanisms that help enable human antibodies to engage conserved sites of vulnerability on influenza virus.
    1. Evolutionary Biology

    Integration of multi-level dental diversity links macro-evolutionary patterns to ecological strategies across sharks

    Roland Zimm, Vitória Tobias Santos, Nicolas Goudemand
    1. Structural Biology and Molecular Biophysics

    Conformational dynamics and asymmetry in multimodal inhibition of membrane-bound pyrophosphatases

    Jianing Liu, Anokhi Shah ... Keni Vidilaseris
    Distinct asymmetric states in membrane-bound pyrophosphatases reveal how inhibitors block their activity and inform drug development.
    1. Cell Biology
    2. Immunology and Inflammation

    Engineered migrasomes provide a robust and thermally stable vaccination platform

    Dongju Wang, Haifang Wang ... Zhihua Liu
    Integration of migrasome-inspired biology with hypotonic shock-mediated vesicle generation establishes a durable and versatile platform for vaccine development.
    1. Developmental Biology
    2. Immunology and Inflammation

    HEB collaborates with TCR signaling to upregulate Id3 and enable γδT17 cell maturation in the fetal thymus

    Johanna S Selvaratnam, Juliana Dutra Barbosa da Rocha ... Michele K Anderson
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Early exercise disrupts a pro-repair extracellular matrix program during zebrafish fin regeneration

    Victor M Lewis, Rafael A Fernandez ... Kryn Stankunas
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    • Incomplete
    1. Immunology and Inflammation

    Contrasting roles for IKK regulated inflammatory signalling pathways for development and maintenance of type 1 and adaptive γδ T cells

    Farjana Islam, Cayman Williams ... Benedict Seddon
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    A comprehensive mechanosensory connectome reveals a somatotopically organized neural circuit architecture controlling stimulus-aimed grooming of the Drosophila head

    Steven A Calle-Schuler, Alexis E Santana-Cruz ... Andrew M Seeds
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Regulation of sensorimotor serial learning in speech production by motor compensation rather than sensory error

    Yuhan Lu, Xiaowei Tang ... Xing Tian
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    DNA tensiometer reveals catch-bond detachment kinetics of kinesin-1, -2 and -3

    Crystal R Noell, Tzu-Chen Ma ... William O Hancock
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    • Incomplete
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Glycolysis-dependent Sulfur Metabolism Orchestrates Morphological Plasticity and Virulence in Fungi

    Dhrumi Shah, Nikita Rewatkar ... Sriram Varahan
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Stem Cells and Regenerative Medicine

    Rejuvenation-Responsive and Senolytic-Sensitive Muscle Stem Cells Unveiled by CD200 and CD63 in Geriatric Muscle

    Ye Lynne Kim, Young-Woo Jo ... Young-Yun Kong
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Neuroscience

    The influence of nucleus accumbens shell D1 and D2 neurons on outcome-specific Pavlovian instrumental transfer

    Octavia Soegyono, Elise Pepin ... Vincent Laurent
    Cell-specific manipulations uncover novel mechanisms in the ventral striatum that mediate the influence of environmental stimuli on action selection.
    1. Biochemistry and Chemical Biology

    Membrane-mimetic thermal proteome profiling (MM-TPP) toward mapping membrane protein–ligand dynamic interactions

    Rupinder Singh Jandu, Ashim Bhattacharya ... Franck Duong van Hoa
    Peptidisc-based thermal proteome profiling enables detergent-free mapping of membrane protein–ligand interactions, advancing the discovery of druggable targets in membrane-mimetic environments.
    1. Neuroscience

    Modulation of aperiodic EEG activity provides sensitive index of cognitive state changes during working memory task

    Tisa Frelih, Andraž Matkovič ... Grega Repovš
    A novel analysis reveals distinct periodic and aperiodic EEG activity during working memory, challenging oscillatory-centric views while establishing aperiodic activity as a more sensitive marker of cognitive state.
    1. Cell Biology

    Calcium transfer from the ER to other organelles for optimal signaling in Toxoplasma gondii

    Zhu-Hong Li, Beejan Asady ... Silvia NJ Moreno
    In Toxoplasma gondii, SERCA-driven ER Ca²⁺ uptake sustains homeostasis and enables redistribution to mitochondria and other organelles, highlighting the ER as a central hub in parasite Ca²⁺ signaling and infection.
    1. Computational and Systems Biology
    2. Neuroscience

    Anti-diuretic hormone ITP signals via a guanylate cyclase receptor to modulate systemic homeostasis in Drosophila

    Jayati Gera, Marishia Agard ... Meet Zandawala
    A multi-pronged approach reveals that ion transport peptide neuropeptide acts through the guanylate cyclase receptor Gyc76C to coordinate osmotic and metabolic homeostasis across multiple tissues in Drosophila.
    1. Developmental Biology

    SLC35G3 is a UDP-N-acetylglucosamine transporter for sperm glycoprotein formation and underpins male fertility in mice

    Daisuke Mashiko, Shingo Tonai ... Masahito Ikawa
    SLC35G3-mediated UDP-GlcNAc transport is essential for proper sperm glycoprotein formation and male fertility.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Rearrangement of 3D genome organization in breast cancer epithelial to mesenchymal transition and metastasis organotropism

    Priyojit Das, Rebeca San Martin ... Rachel Patton McCord
    Chromosome compartment analysis of a cancer cell line cohort reveals different subsets of compartment changes where some track epithelial to mesenchymal transition while others reflect secondary metastatic organ-specific reorganizations.
    1. Neuroscience

    Animacy semantic network supports causal inferences about illness

    Miriam Hauptman, Marina Bedny
    Making causal inferences about illness, compared to making causal inferences about mechanical breakdown and reading causally unconnected sentences, activates a semantic brain network implicated in the conceptual representation of animate entities (e.g. people, animals).
    1. Cancer Biology

    PTEN restrains SHH medulloblastma growth through cell autonomous and nonautonomous mechanisms

    Zhimin Lao, Salsabiel El Nagar ... Alexandra L Joyner
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Cell Biology
    2. Physics of Living Systems

    The titin N2A-MARP signalosome constrains muscle longitudinal hypertrophy in response to stretch

    Robbert van der Pijl, Jochen Gohlke ... Coen Ottenheijm
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Cohesin reconstitution and homologous recombination repair of DNA double-strand breaks in late mitosis

    Jessel Ayra Plasencia, Sara Medina-Suárez ... Félix Machín
    The cohesin subunit Scc1 returns and reconstitutes the complex with Smc1–Smc3 in late mitosis upon DNA double-strand breaks, although it does not participate in homologous recombination-driven MAT switching.
    Version of Record
    Short Report
    • Valuable
    • Convincing
    1. Ecology
    2. Neuroscience

    Individual recognition in a jumping spider (Phidippus regius)

    Christoph D Dahl, Yaling Cheng
    A jumping spider discriminates familiar from novel conspecifics for hours, indicating recognition and long-term memory in a miniature-brained, asocial arthropod, highlighting learning and internal representations in small nervous systems.
    1. Genetics and Genomics

    Independent validation of transgenerational inheritance of learned pathogen avoidance in Caenorhabditis elegans

    Aalimah Akinosho, Joseph Alexander ... Andres Gabriel Vidal-Gadea
    Independent replication confirms that avoidance of pathogenic PA14 learned by Caenorhabditis elegans persists through the F2 generation using standardized sodium azide immobilization choice assays, clarifying prior reproducibility concerns.
    1. Ecology

    Assessing plant phenological changes based on drivers of spring phenology

    Yong Jiang, Stephen J Mayor ... Qing-Lai Dang
    A new method to partition observed phenological changes based on drivers of spring phenology has been presented.
    1. Neuroscience

    Type-I nNOS neurons orchestrate cortical neural activity and vasomotion

    Kevin Turner, Dakota Brockway ... Patrick J Drew
    Removal of type-I nNOS neurons decreased delta-band power in the LFP, lowered dilation to sustained stimulation, decreased the interhemispheric coherence of neural and hemodynamic signals, and reduced vasomotion amplitude.
    1. Ecology

    Early experience affects foraging behavior of wild fruit bats more than their original behavioral predispositions

    Adi Rachum, Lee M Harten ... Yossi Yovel
    Early-life environment shapes how wild bats behave as adults, showing that developmental experience, rather than innate predisposition, drives individual differences in foraging behavior.
    1. Chromosomes and Gene Expression

    Acetylation of H3K115 is associated with fragile nucleosomes at CpG island promoters and active regulatory sites

    Yatendra Kumar, Dipta Sengupta ... Wendy A Bickmore
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology
    2. Medicine

    NAD+ boosting by oral nicotinamide mononucleotide administration regulates key metabolic and immune pathways through SIRT1 dependent and independent mechanisms to mitigate diet-induced obesity and dyslipidemia in mice

    Yasser Majeed, Najeeb M Halabi ... Nayef A Mazloum
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Immunology and Inflammation

    Ex vivo and in vivo CRISPR/Cas9 screenings identify the roles of protein N-glycosylation in regulating T-cell activation and functions

    Yu Hong, Xiaofang Si ... Yu Zhang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Eye-specific differences in active zone addition during synaptic competition in the developing visual system

    Chenghang Zhang, Tarlan Vatan, Colenso M Speer
    Eye-specific differences in presynaptic release site addition and clustering correlate with axonal segregation outcomes during retinogeniculate refinement in the mouse.
    1. Evolutionary Biology

    Parallel HIV-1 fitness landscapes shape viral dynamics in humans and macaques that develop broadly neutralizing antibodies

    Kai S Shimagaki, Rebecca M Lynch, John P Barton
    Fitness constraints on the HIV envelope protein are highly similar in humans and rhesus macaques, emphasizing the utility of macaque models of infection and antibody development.
    1. Developmental Biology

    A tissue boundary orchestrates the segregation of inner ear sensory organs

    Ziqi Chen, Magdalena Żak ... Nicolas Daudet
    A boundary between the sensory and nonsensory domains contains cells that undergo a series of morphological changes and form basal constriction to separate the segregating inner ear sensory organs.
    1. Developmental Biology
    2. Neuroscience

    Cell cycle-dependent cues regulate temporal patterning of the Drosophila central brain neural stem cells

    Gonzalo N Morales Chaya, Mubarak Hussain Syed
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Genetics and Genomics
    2. Ecology

    Microbial consortia in salt marsh sediments are sequentially buried over millennia and genomic complementarity analysis indicates an important role in complex carbon decomposition

    Joseph H Vineis, Ashley N Bulseco ... Jennifer L Bowen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Structural Biology and Molecular Biophysics

    Enhanced Processivity and Collective Force Production of Kinesins at Low Radial Forces

    Andrew M Hensley, Ahmet Yildiz
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Rhythmic sampling and competition of target and distractor in a motion detection task

    Changhao Xiong, Nathan M Petro ... Mingzhou Ding
    Spatially and temporally overlapping target and distractor are both rhythmically sampled at ~1 Hz, and the phase relationship between target sampling and distractor sampling predicts behavior.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Roles of the membrane-binding motif and the C-terminal domain of RNase E in localization and diffusion in E. coli

    Laura Troyer, Yu-Huan Wang ... Sangjin Kim
    Single-molecule imaging uncovers how distinct membrane-binding motifs and the intrinsically disordered C-terminal domain control RNase E’s membrane association and diffusion, linking structural divergence to RNA-processing dynamics in bacteria.
    1. Neuroscience

    Extracting Value Coding Features from Individual Serotonin Neurons

    Emerson F Harkin, Jean-Claude Béïque, Richard Naud
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    A Toolkit for In Vivo Mapping and Modulating Neurotransmission at Single-Cell Resolution

    Andrea Cuentas-Condori, Patricia Chanabá-López ... Daniel Colón-Ramos
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Longitudinal awake imaging of mouse deep brain microvasculature with super-resolution ultrasound localization microscopy

    Yike Wang, Matthew R Lowerison ... Pengfei Song
    Ultrasound localization microscopy in awake mice enables high-resolution imaging of cerebral microvasculature in a natural physiological state, eliminates confounding effects of anesthetics, and supports reliable longitudinal vascular assessment across weeks.
    1. Neuroscience

    High cognitive violation of expectations is compromised in cerebellar ataxia

    Leonardo Daniel, Eli Vakil, William Saban
    Across three experiments, the cerebellum was found to support discrete sequential problems in higher cognition by processing expectation violations.
    1. Neuroscience

    Identifying regulators of associative learning using a protein-labelling approach in C. elegans

    Aelon Rahmani, Anna McMillen ... Yee Lian Chew
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Neuroscience

    Currentscape analysis of dendritic inputs during place field dynamics

    Bence Fogel, Balázs B Ujfalussy
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Solid
    1. Neuroscience
    2. Computational and Systems Biology

    The time course of visuo-semantic representations in the human brain is captured by combining vision and language models

    Boyan Rong, Alessandro Thomas Gifford ... Radoslaw Martin Cichy
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Neuroscience

    Multi-timescale neural adaptation underlying long-term musculoskeletal reorganization

    Roland Philipp, Yuki Hara ... Kazuhiko Seki
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Epidemiology and Global Health

    Spatiotemporal relationships between extreme weather events and arbovirus transmission across Brazil

    Victoria M Cox, Felipe Campos de Melo Iani ... Ilaria Dorigatti
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Developmental Biology

    Sox9 prevents retinal degeneration and is required for limbal stem cell differentiation in the adult mouse eye

    Alicia Hurtado, Victor López-Soriano ... Francisco Javier Barrionuevo
    The Sox9 gene is necessary for maintaining vision in the mouse adult eye, acting as an essential factor for retinal and corneal function.
    1. Ecology

    Birds migrate longitudinally in response to the resultant Asian monsoons of the Qinghai-Tibet Plateau uplift

    Wenyuan Zhang, Zhongru Gu ... Xiangjiang Zhan
    The uplift of the Qinghai-Tibet Plateau redirected avian migrations from latitudinal to longitudinal paths through induced monsoon systems, fundamentally reshaping continental biogeographic patterns.
    Version of Record
    Short Report
    • Important
    • Solid
    1. Neuroscience

    Mixed evidence for the rhythmicity of auditory perceptual judgements in humans

    Cécile Fabio, Christoph Kayser
    Across multiple experiments, the evidence for any rhythmicity of auditory perception remains difficult to establish.
    1. Evolutionary Biology

    Convergent iridescence and divergent chemical signals in sympatric sister-species of Amazonian butterflies

    Joséphine Ledamoisel, Bruno Buatois ... Violaine Llaurens
    Ecological interactions exert contrasting evolutionary pressures on sympatric Morpho butterflies, promoting convergence in iridescence but divergence in chemical cues, illustrating how ecological interactions mediate trait evolution and sister-species coexistence.
    1. Evolutionary Biology

    Heterozygosity at a conserved candidate sex determination locus is associated with female development in the clonal raider ant (Ooceraea biroi)

    Kip D Lacy, Jina Lee ... Daniel JC Kronauer
    A complementary sex determination locus is conserved in ants and dates back to approximately 112 million years ago.
    1. Immunology and Inflammation

    Layers of immunity: Deconstructing the Drosophila effector response

    Faustine Ryckebusch, Yao Tian ... Bruno Lemaitre
    New tools make it possible to investigate the timing and importance of different immune effectors in defense against infection.
    1. Microbiology and Infectious Disease

    Quinolines interfere with heme-mediated activation of artemisinins

    Melissa R Rosenthal, Daniel E Goldberg
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Biochemistry and Chemical Biology

    Integrated Respirometry and Metabolomics Unveil Circadian Metabolic Dynamics in Drosophila

    Farheen Akhtar, Dania Malik ... Aalim M Weljie
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Medicine

    Cell-autonomous and non-cell-autonomous effects of Arginase 2 on cardiac aging

    Duilio M Potenza, Xin Cheng ... Xiu-Fen Ming
    Arginase 2 in macrophages promotes cardiac aging phenotype via paracrine release of IL-1β.
    1. Neuroscience

    Characterization of postsynaptic glutamate transporter functionality in the zebrafish retinal first synapse across different wavelengths

    Marco Garbelli, Stephanie Niklaus, Stephan CF Neuhauss
    Loss of the glutamate transporters EAAT5b and EAAT7 disrupts wavelength-specific visual processing and UV-dependent prey detection in zebrafish, revealing their key roles in modulating light integration and behaviorally relevant vision.
    1. Neuroscience

    Misclassification in memory modification in AppNL-G-F knock-in mouse model of Alzheimer’s disease

    Mei-Lun Huang, Yusuke Suzuki ... Itaru Imayoshi
    Computational modeling of the memory modification process reveals biased internal states in an Alzheimer’s disease mouse model, providing a new approach for early cognitive assessment and diagnosis.
    1. Computational and Systems Biology
    2. Neuroscience

    Correlation detection as a stimulus computable account for audiovisual perception, causal inference, and saliency maps in mammals

    Cesare V Parise
    Optimal cue integration, Bayesian Causal Inference, spatial orienting, speech illusions and other key phenomena in audiovisual perception naturally emerge from the collective behavior of a population of Multisensory Correlation Detector.
    1. Evolutionary Biology

    Inference of germinal center evolutionary dynamics via simulation-based deep learning

    Duncan K Ralph, Athanasios G Bakis ... Frederick A Matsen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Ecology
    2. Computational and Systems Biology

    vassi – verifiable, automated scoring of social interactions in animal groups

    Paul Nührenberg, Aneesh PH Bose, Alex Jordan
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Cell Biology
    2. Developmental Biology

    Glucose-stimulated KIF5B-driven microtubule sliding organizes microtubule networks in mouse pancreatic β cells

    Kai M Bracey, Margret A Fye ... Irina Kaverina
    Sub-membrane microtubule array, known to prevent excessive glucose-stimulated insulin secretion, depends on kinesin-1 KIF5B, which moves microtubules to both generate and remodel this array, potentially regulating the dosage of secretion.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Characterization of binding kinetics and intracellular signaling of new psychoactive substances targeting cannabinoid receptor using transition-based reweighting method

    Soumajit Dutta, Diwakar Shukla
    New psychoactive substances activate cannabinoid receptors using distinct ligand-receptor interactions.
    1. Biochemistry and Chemical Biology

    Insight into the bioactivity and action mode of betulin, a candidate aphicide from plant metabolite, against aphids

    Junxiu Wang, Matthana Klakong ... Hong Zhou
    The insecticidal activity of betulin, a plant-derived metabolite, against the peach aphid depends on specific targeting and inhibition of MpGABR.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Short heat shock factor A2 regulates heat resistance and growth balance in Arabidopsis

    Wanxia Chen, Jiaqi Zhao ... Xiaoting Qi
    Short heat shock factor variants prevent hyperactivation of thermotolerance through a noncanonical heat shock response, thereby balancing heat stress response and plant growth.
    1. Biochemistry and Chemical Biology

    Engineering NIR-sighted bacteria

    Stefanie SM Meier, Michael Hörzing ... Andreas Möglich
    Custom-tailored bathy-phytochromes control bacterial gene expression by near-infrared light while exhibiting minimal response to red light, thus unlocking innovative application scenarios.
    1. Neuroscience

    Relative timescale of channel voltage dependence and channel density regulation impacts assembly and recovery of activity

    Yugarshi Mondal, Ronald L Calabrese, Eve Marder
    Ion channel voltage-dependence alterations can shape intrinsic homeostatic plasticity, even if operating faster than other intrinsic regulatory processes—where timescale separation would suggest its influence should be negligible.

Magazine

  1. Research Culture: The SAFE Labs Handbook as a tool for improving lab culture

    Erika Donà, James M Gahan ... Philip Coen
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Metabolism: How one nutrient controls cell size

    Angela Montero, Lydia WS Finley
    1. Genetics and Genomics

    Transgenerational Epigenetic Inheritance: Twists and turns in the story of learned avoidance

    Lesley T MacNeil
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease
    3. Medicine

    Focus Issue: Trained Immunity

    Edited by Satyajit Rath et al.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Focus Issue: Evolving our understanding of trained immunity

    Eva Kaufmann, Yahya Sohrabi ... Jos WM van der Meer
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Bacteriology: How Shigella tackles host defences

    Yizhou Huang, Teresa LM Thurston