TY - JOUR TI - Integrative genomic analysis of the human immune response to influenza vaccination AU - Franco, Luis M AU - Bucasas, Kristine L AU - Wells, Janet M AU - NiƱo, Diane AU - Wang, Xueqing AU - Zapata, Gladys E AU - Arden, Nancy AU - Renwick, Alexander AU - Yu, Peng AU - Quarles, John M AU - Bray, Molly S AU - Couch, Robert B AU - Belmont, John W AU - Shaw, Chad A A2 - Dermitzakis, Emmanouil T VL - 2 PY - 2013 DA - 2013/07/16 SP - e00299 C1 - eLife 2013;2:e00299 DO - 10.7554/eLife.00299 UR - https://doi.org/10.7554/eLife.00299 AB - Identification of the host genetic factors that contribute to variation in vaccine responsiveness may uncover important mechanisms affecting vaccine efficacy. We carried out an integrative, longitudinal study combining genetic, transcriptional, and immunologic data in humans given seasonal influenza vaccine. We identified 20 genes exhibiting a transcriptional response to vaccination, significant genotype effects on gene expression, and correlation between the transcriptional and antibody responses. The results show that variation at the level of genes involved in membrane trafficking and antigen processing significantly influences the human response to influenza vaccination. More broadly, we demonstrate that an integrative study design is an efficient alternative to existing methods for the identification of genes involved in complex traits. KW - Complex-trait genetic KW - Vaccine KW - Human genetic KW - Integrative biology KW - Systems biology KW - eQTL JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -