1. Human Biology and Medicine
Download icon

Human Genetics: Immune response is a personal matter

  1. Pedro G Ferreira  Is a corresponding author
  2. Emmanouil T Dermitzakis  Is a corresponding author
  1. University of Geneva Medical School, Switzerland
Insight
Cite this article as: eLife 2013;2:e00899 doi: 10.7554/eLife.00899
1 figure

Figures

Lower panel: Genetic variants that regulate the expression of other genes are known as expression quantitative trait loci (eQTL) and they are typically found close to the transcription start site (arrow) of the gene that they regulate (blue rectangle). However, they also occur in exons and may thus affect the structure and stability of messenger RNA transcripts (Montgomery et al., 2010; Pickrell et al., 2010). Upper panel: Left, although the majority of genes do not show altered expression in response to vaccination, a minority do show different levels of expression before and afterwards. Centre, these changes in expression are influenced by the individual’s genotype at other loci. Right, for some genes, changes in expression correlate with the individual’s antibody response to vaccination. These genes could be used as biomarkers to predict whether an individual will respond successfully to a vaccine.

Download links

A two-part list of links to download the article, or parts of the article, in various formats.

Downloads (link to download the article as PDF)

Download citations (links to download the citations from this article in formats compatible with various reference manager tools)

Open citations (links to open the citations from this article in various online reference manager services)