1. Cell Biology
  2. Neuroscience
Download icon

Neuroscience: Endocytosis gets in tune with action potential bursts

  1. Melissa A Herman  Is a corresponding author
  2. Christian Rosenmund  Is a corresponding author
  1. Charité Universitätsmedizin Berlin, Germany
Cite this article as: eLife 2013;2:e01234 doi: 10.7554/eLife.01234
1 figure


Changes in the speed of endocytosis and the underlying signalling pathways. (A) Schematic representation of the relationship between the speed of endocytosis, the level of intracellular calcium produced by increasing numbers of action potentials, and the signalling pathways activated by intracellular calcium when there is just a single action potential (i), a small burst of action potentials (ii), and a large burst of action potentials (iii). (B) Calcium levels are low when there is just one action potential (i), so calcineurin (CaN) is not activated, allowing Cdk5 to maintain high levels of phosphorylation of dynamin (P-dynamin). As the number of action potentials increases (ii), there are more calcium ions to activate the calcineurin, which results in a shift towards dephosphorylated dynamin. This can then bind to syndapin, and this interaction increases the rate of endocytosis. However, as the number of action potentials, and hence calcium levels, increase further (iii), a second calcium-dependent pathway with unknown molecular components is activated, and this reduces the rate of endocytosis.

Download links

A two-part list of links to download the article, or parts of the article, in various formats.

Downloads (link to download the article as PDF)

Download citations (links to download the citations from this article in formats compatible with various reference manager tools)

Open citations (links to open the citations from this article in various online reference manager services)