TY - JOUR TI - TAF7L modulates brown adipose tissue formation AU - Zhou, Haiying AU - Wan, Bo AU - Grubisic, Ivan AU - Kaplan, Tommy AU - Tjian, Robert A2 - Kadonaga, James T VL - 3 PY - 2014 DA - 2014/05/29 SP - e02811 C1 - eLife 2014;3:e02811 DO - 10.7554/eLife.02811 UR - https://doi.org/10.7554/eLife.02811 AB - Brown adipose tissue (BAT) plays an essential role in metabolic homeostasis by dissipating energy via thermogenesis through uncoupling protein 1 (UCP1). Previously, we reported that the TATA-binding protein associated factor 7L (TAF7L) is an important regulator of white adipose tissue (WAT) differentiation. In this study, we show that TAF7L also serves as a molecular switch between brown fat and muscle lineages in vivo and in vitro. In adipose tissue, TAF7L-containing TFIID complexes associate with PPARĪ³ to mediate DNA looping between distal enhancers and core promoter elements. Our findings suggest that the presence of the tissue-specific TAF7L subunit in TFIID functions to promote long-range chromatin interactions during BAT lineage specification. KW - PPARĪ³ KW - DNA looping KW - UCP1 KW - BAT KW - obesity JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -