Figures and data in Autism and attention-deficit/hyperactivity disorder among individuals with a family history of alcohol use disorders

4 tables

Tables

Table 1

Basic characteristics of patients with autism and ADHD

https://doi.org/10.7554/eLife.02917.003

Table 2

Risk of autism and ADHD in offspring when their parents were diagnosed with alcohol use disorder (AUD)

https://doi.org/10.7554/eLife.02917.004

AUD in parent	No. of offspring at risk	Person-years of follow-up	Autism				ADHD
AUD in parent	No. of offspring at risk	Person-years of follow-up	O	SIR	95% CI		O	SIR	95% CI
Risk in sons
Father	235696	4485707	1793	1.39	1.33	1.45	5548	2.17	2.11	2.22
Mother	69214	1344766	567	1.55	1.43	1.69	1952	2.73	2.61	2.85
Parents	289763	5540362	2203	1.41	1.35	1.47	6800	2.20	2.15	2.25
Risk in daughters
Father	225317	4306194	753	1.31	1.22	1.4	2609	2.12	2.04	2.21
Mother	65,479	1275507	245	1.50	1.32	1.7	970	2.77	2.60	2.95
Parents	276439	5305285	933	1.34	1.25	1.43	3247	2.18	2.10	2.25
Risk in offspring
Father	461013	8791901	2546	1.36	1.31	1.42	8157	2.15	2.11	2.20
Mother	134693	2620273	812	1.54	1.43	1.65	2922	2.74	2.64	2.84
Parents	566202	10845647	3136	1.39	1.34	1.44	10,047	2.19	2.15	2.23
PAF			3.6%				11%

O, observed number of cases; SIR, standardized incidence ratio; CI, confidence interval.
Bold type, 95% CI does not include 1.00.
PAF, population attributable fraction.

Table 3

Risk of autism and ADHD in offspring when their parents were diagnosed with alcohol use disorder (AUD) before the birth of the offspring

https://doi.org/10.7554/eLife.02917.005

AUD in parent	No. of offspring at risk	Person-years of follow-up	Autism				ADHD
AUD in parent	No. of offspring at risk	Person-years of follow-up	O	SIR	95% CI		O	SIR	95% CI
Risk in sons
Father	41832	410327	442	1.44	1.31	1.59	1555	2.60	2.48	2.74
Mother	8776	80,689	99	1.67	1.35	2.03	347	3.14	2.82	3.49
Parents	48704	472596	514	1.46	1.34	1.59	1778	2.61	2.49	2.73
Risk in daughters
Father	39684	390429	145	1.40	1.18	1.64	565	3.05	2.80	3.31
Mother	8457	77259	36	1.79	1.25	2.48	119	3.44	2.85	4.12
Parents	46299	450022	175	1.47	1.26	1.70	634	3.00	2.77	3.24
Risk in offspring
Father	81516	800756	587	1.43	1.32	1.55	2120	2.71	2.59	2.83
Mother	17233	157948	135	1.70	1.42	2.01	466	3.22	2.93	3.52
Parents	95003	922618	689	1.46	1.36	1.58	2412	2.70	2.59	2.81

O, observed number of cases; SIR, standardized incidence ratio; CI, confidence interval.
Bold type, 95% CI does not include 1.00.

Table 4

Risk of autism and ADHD in adoptees when their biological or adoptive parents were diagnosed with alcohol use disorder (AUD)

https://doi.org/10.7554/eLife.02917.006

	No. of offspring at risk	Person-years of follow-up	Autism				ADHD
	No. of offspring at risk	Person-years of follow-up	O	SIR	95% CI		O	SIR	95% CI
Biological parents with AUD
Father	2175	51746	16	2.15	1.23	3.50	53	2.63	1.97	3.44
Mother	1381	32745	10	1.81	0.86	3.35	18	1.21	0.72	1.92
Parents	3251	77310	19	1.75	1.05	2.74	58	1.91	1.45	2.47
Adoptive parents with AUD
Father	457	10,839	1	0.75	0.00	4.28	7	1.78	0.70	3.68
Mother	229	5443	0				4	1.93	0.50	4.98
Parents	654	15546	1	0.51	0.00	2.93	9	1.59	0.72	3.04

O, observed number of cases; SIR, standardized incidence ratio; CI, confidence interval.
Bold type, 95% CI does not include 1.00.

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(2014)

Autism and attention-deficit/hyperactivity disorder among individuals with a family history of alcohol use disorders

eLife 3:e02917.

https://doi.org/10.7554/eLife.02917