TY - JOUR TI - Nuclear envelope protein MAN1 regulates clock through BMAL1 AU - Lin, Shu-Ting AU - Zhang, Luoying AU - Lin, Xiaoyan AU - Zhang, Linda Chen AU - Garcia, Valentina Elizabeth AU - Tsai, Chen-Wei AU - Ptáček, Louis AU - Fu, Ying-Hui A2 - Griffith, Leslie C VL - 3 PY - 2014 DA - 2014/09/02 SP - e02981 C1 - eLife 2014;3:e02981 DO - 10.7554/eLife.02981 UR - https://doi.org/10.7554/eLife.02981 AB - Circadian clocks serve as internal pacemakers that influence many basic homeostatic processes; consequently, the expression and function of their components are tightly regulated by intricate networks of feedback loops that fine-tune circadian processes. Our knowledge of these components and pathways is far from exhaustive. In recent decades, the nuclear envelope has emerged as a global gene regulatory machine, although its role in circadian regulation has not been explored. We report that transcription of the core clock component BMAL1 is positively modulated by the inner nuclear membrane protein MAN1, which directly binds the BMAL1 promoter and enhances its transcription. Our results establish a novel connection between the nuclear periphery and circadian rhythmicity, therefore bridging two global regulatory systems that modulate all aspects of bodily functions. KW - nuclear envelope KW - circadian rhythm KW - MAN1 KW - BMAL1 JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -