TY - JOUR TI - Functional fission of parvalbumin interneuron classes during fast network events AU - Varga, Csaba AU - Oijala, Mikko AU - Lish, Jonathan AU - Szabo, Gergely G AU - Bezaire, Marianne AU - Marchionni, Ivan AU - Golshani, Peyman AU - Soltesz, Ivan A2 - Skinner, Frances K VL - 3 PY - 2014 DA - 2014/11/06 SP - e04006 C1 - eLife 2014;3:e04006 DO - 10.7554/eLife.04006 UR - https://doi.org/10.7554/eLife.04006 AB - Fast spiking, parvalbumin (PV) expressing hippocampal interneurons are classified into basket, axo-axonic (chandelier), and bistratified cells. These cell classes play key roles in regulating local circuit operations and rhythmogenesis by releasing GABA in precise temporal patterns onto distinct domains of principal cells. In this study, we show that each of the three major PV cell classes further splits into functionally distinct sub-classes during fast network events in vivo. During the slower (<10 Hz) theta oscillations, each cell class exhibited its own characteristic, relatively uniform firing behavior. However, during faster (>90 Hz) oscillations, within-class differences in PV interneuron discharges emerged, which segregated along specific features of dendritic structure or somatic location. Functional divergence of PV sub-classes during fast but not slow network oscillations effectively doubles the repertoire of spatio-temporal patterns of GABA release available for rapid circuit operations. KW - oscillation KW - inhibition KW - in vivo JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -