TY - JOUR TI - Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses AU - Chiba, Shiho AU - Ikushima, Hiroaki AU - Ueki, Hiroshi AU - Yanai, Hideyuki AU - Kimura, Yoshitaka AU - Hangai, Sho AU - Nishio, Junko AU - Negishi, Hideo AU - Tamura, Tomohiko AU - Saijo, Shinobu AU - Iwakura, Yoichiro AU - Taniguchi, Tadatsugu A2 - Medzhitov, Ruslan VL - 3 PY - 2014 DA - 2014/08/22 SP - e04177 C1 - eLife 2014;3:e04177 DO - 10.7554/eLife.04177 UR - https://doi.org/10.7554/eLife.04177 AB - The eradication of tumor cells requires communication to and signaling by cells of the immune system. Natural killer (NK) cells are essential tumor-killing effector cells of the innate immune system; however, little is known about whether or how other immune cells recognize tumor cells to assist NK cells. Here, we show that the innate immune receptor Dectin-1 expressed on dendritic cells and macrophages is critical to NK-mediated killing of tumor cells that express N-glycan structures at high levels. Receptor recognition of these tumor cells causes the activation of the IRF5 transcription factor and downstream gene induction for the full-blown tumoricidal activity of NK cells. Consistent with this, we show exacerbated in vivo tumor growth in mice genetically deficient in either Dectin-1 or IRF5. The critical contribution of Dectin-1 in the recognition of and signaling by tumor cells may offer new insight into the anti-tumor immune system with therapeutic implications. KW - innate immunity KW - Dectin-1 KW - NK cell KW - IRF JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -