TY - JOUR TI - Closing in on a mechanism for activation AU - Hubbard, Stevan R AU - Miller, W Todd VL - 3 PY - 2014 DA - 2014/10/28 SP - e04909 C1 - eLife 2014;3:e04909 DO - 10.7554/eLife.04909 UR - https://doi.org/10.7554/eLife.04909 AB - When insulin-like growth factor-1 (IGF1) binds to its receptor, a physical constraint is released that allows the two transmembrane helices to come together to facilitate activation of the receptor. KW - IGF1 receptor KW - mechanism KW - FRET KW - kinetic JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -