TY - JOUR TI - Synaptic representation of locomotion in single cerebellar granule cells AU - Powell, Kate AU - Mathy, Alexandre AU - Duguid, Ian AU - Häusser, Michael A2 - Raman, Indira M VL - 4 PY - 2015 DA - 2015/06/17 SP - e07290 C1 - eLife 2015;4:e07290 DO - 10.7554/eLife.07290 UR - https://doi.org/10.7554/eLife.07290 AB - The cerebellum plays a crucial role in the regulation of locomotion, but how movement is represented at the synaptic level is not known. Here, we use in vivo patch-clamp recordings to show that locomotion can be directly read out from mossy fiber synaptic input and spike output in single granule cells. The increase in granule cell spiking during locomotion is enhanced by glutamate spillover currents recruited during movement. Surprisingly, the entire step sequence can be predicted from input EPSCs and output spikes of a single granule cell, suggesting that a robust gait code is present already at the cerebellar input layer and transmitted via the granule cell pathway to downstream Purkinje cells. Thus, synaptic input delivers remarkably rich information to single neurons during locomotion. KW - patch clamp KW - granule cell KW - cerebellum KW - locomotion KW - synaptic integration JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -