TY - JOUR TI - Functional effects of distinct innervation styles of pyramidal cells by fast spiking cortical interneurons AU - Kubota, Yoshiyuki AU - Kondo, Satoru AU - Nomura, Masaki AU - Hatada, Sayuri AU - Yamaguchi, Noboru AU - Mohamed, Alsayed A AU - Karube, Fuyuki AU - Lübke, Joachim AU - Kawaguchi, Yasuo A2 - Bartos, Marlene VL - 4 PY - 2015 DA - 2015/07/04 SP - e07919 C1 - eLife 2015;4:e07919 DO - 10.7554/eLife.07919 UR - https://doi.org/10.7554/eLife.07919 AB - Inhibitory interneurons target precise membrane regions on pyramidal cells, but differences in their functional effects on somata, dendrites and spines remain unclear. We analyzed inhibitory synaptic events induced by cortical, fast-spiking (FS) basket cells which innervate dendritic shafts and spines as well as pyramidal cell somata. Serial electron micrograph (EMg) reconstructions showed that somatic synapses were larger than dendritic contacts. Simulations with precise anatomical and physiological data reveal functional differences between different innervation styles. FS cell soma-targeting synapses initiate a strong, global inhibition, those on shafts inhibit more restricted dendritic zones, while synapses on spines may mediate a strictly local veto. Thus, FS cell synapses of different sizes and sites provide functionally diverse forms of pyramidal cell inhibition. KW - inhibitory synapse KW - FS basket cell KW - pyramidal cell KW - IPSC KW - spine KW - synaptic conductance JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -