TY - JOUR TI - Food odors trigger Drosophila males to deposit a pheromone that guides aggregation and female oviposition decisions AU - Lin, Chun-Chieh AU - Prokop-Prigge, Katharine A AU - Preti, George AU - Potter, Christopher J A2 - Ramaswami, Mani VL - 4 PY - 2015 DA - 2015/09/30 SP - e08688 C1 - eLife 2015;4:e08688 DO - 10.7554/eLife.08688 UR - https://doi.org/10.7554/eLife.08688 AB - Animals use olfactory cues for navigating complex environments. Food odors in particular provide crucial information regarding potential foraging sites. Many behaviors occur at food sites, yet how food odors regulate such behaviors at these sites is unclear. Using Drosophila melanogaster as an animal model, we found that males deposit the pheromone 9-tricosene upon stimulation with the food-odor apple cider vinegar. This pheromone acts as a potent aggregation pheromone and as an oviposition guidance cue for females. We use genetic, molecular, electrophysiological, and behavioral approaches to show that 9-tricosene activates antennal basiconic Or7a receptors, a receptor activated by many alcohols and aldehydes such as the green leaf volatile E2-hexenal. We demonstrate that loss of Or7a positive neurons or the Or7a receptor abolishes aggregation behavior and oviposition site-selection towards 9-tricosene and E2-hexenal. 9-Tricosene thus functions via Or7a to link food-odor perception with aggregation and egg-laying decisions. KW - olfaction KW - pheromone KW - oviposition KW - aggregation JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -