TY - JOUR TI - NG2 glia are required for vessel network formation during embryonic development AU - Minocha, Shilpi AU - Valloton, Delphine AU - Brunet, Isabelle AU - Eichmann, Anne AU - Hornung, Jean-Pierre AU - Lebrand, Cecile A2 - Gleeson, Joseph G VL - 4 PY - 2015 DA - 2015/12/10 SP - e09102 C1 - eLife 2015;4:e09102 DO - 10.7554/eLife.09102 UR - https://doi.org/10.7554/eLife.09102 AB - The NG2+ glia, also known as polydendrocytes or oligodendrocyte precursor cells, represent a new entity among glial cell populations in the central nervous system. However, the complete repertoire of their roles is not yet identified. The embryonic NG2+ glia originate from the Nkx2.1+ progenitors of the ventral telencephalon. Our analysis unravels that, beginning from E12.5 until E16.5, the NG2+ glia populate the entire dorsal telencephalon. Interestingly, their appearance temporally coincides with the establishment of blood vessel network in the embryonic brain. NG2+ glia are closely apposed to developing cerebral vessels by being either positioned at the sprouting tip cells or tethered along the vessel walls. Absence of NG2+ glia drastically affects the vascular development leading to severe reduction of ramifications and connections by E18.5. By revealing a novel and fundamental role for NG2+ glia, our study brings new perspectives to mechanisms underlying proper vessels network formation in embryonic brains. KW - Nkx2.1 KW - OPCs KW - polydendrocyte KW - NG2+ glia KW - angiogenesis JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -