TY - JOUR TI - Auxin-regulated chromatin switch directs acquisition of flower primordium founder fate AU - Wu, Miin-Feng AU - Yamaguchi, Nobutoshi AU - Xiao, Jun AU - Bargmann, Bastiaan AU - Estelle, Mark AU - Sang, Yi AU - Wagner, Doris A2 - Bergmann, Dominique C VL - 4 PY - 2015 DA - 2015/10/13 SP - e09269 C1 - eLife 2015;4:e09269 DO - 10.7554/eLife.09269 UR - https://doi.org/10.7554/eLife.09269 AB - Reprogramming of cell identities during development frequently requires changes in the chromatin state that need to be restricted to the correct cell populations. Here we identify an auxin hormone-regulated chromatin state switch that directs reprogramming from transit amplifying to primordium founder cell fate in Arabidopsis inflorescences. Upon auxin sensing, the MONOPTEROS transcription factor recruits SWI/SNF chromatin remodeling ATPases to increase accessibility of the DNA for induction of key regulators of flower primordium initiation. In the absence of the hormonal cue, auxin sensitive Aux/IAA proteins bound to MONOPTEROS block recruitment of the SWI/SNF chromatin remodeling ATPases in addition to recruiting a co-repressor/histone deacetylase complex. This simple and elegant hormone-mediated chromatin state switch is ideally suited for iterative flower primordium initiation and orchestrates additional auxin-regulated cell fate transitions. Our findings establish a new paradigm for nuclear response to auxin. They also provide an explanation for how this small molecule can direct diverse plant responses. KW - auxin response KW - flower primordium initiation KW - auxin response factor 5/MONOPTEROS KW - chromatin remodeling KW - aux/IAA KW - arabidopsis thaliana JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -