Sex peptide (SP) and juvenile hormone alter food intake, receptivity to mating, egg production (oogenesis), immunity, lifespan and many other aspects of female physiology upon mating (shown in black). There is evidence that both sex peptide and juvenile hormone can influence many of these processes. Although sex peptide induces the production and release of juvenile hormone, it is not clear whether all the effects of sex peptide on the females are due to the release of this hormone. Reiff et al. add to this model by showing (highlighted in red) that remodeling of the midgut, increased lipid metabolism, egg production and other important changes in female flies depend upon juvenile hormone signaling, which increases after mating (Reiff et al., 2015).