1. Cell Biology
  2. Chromosomes and Gene Expression
Download icon

Aging: Stressing about misplaced fat is a key to longevity

  1. George A Lemieux
  2. Kaveh Ashrafi  Is a corresponding author
  1. University of California, United States
Insight
Cite this article as: eLife 2015;4:e10161 doi: 10.7554/eLife.10161
1 figure

Figures

How the accumulation of fats leads to increased longevity in mutant worms.

Intestinal fat is derived from different sources including dietary fatty acids, new (de novo) synthesis and cell compartments called lysosomes (LYS). In wildtype hermaphrodite worms (left), lipids are packaged into yolk particles (YP), which are then secreted into a cavity called the pseudocoelom and taken up by egg cells (oocytes) in the germ line. The signals that promote yolk production have not yet been identified, but are likely to come from cells in the somatic gonad (dotted arrow). In the glp-1 mutants (right), the stem cells that give rise to the egg cells are absent: however, these sterile worms still produce yolk particles, which accumulate in the body and trigger a stress response. This response involves lipase enzymes (not shown) within the lysosomes that produce metabolites of oleic acid (OA). These molecules act as signaling molecules to activate, either directly or indirectly, the transcription factors NHR-80 and SKN-1, which promote longevity. One of the roles of SKN-1 is to limit the accumulation of fat and yolk.

Download links

A two-part list of links to download the article, or parts of the article, in various formats.

Downloads (link to download the article as PDF)

Download citations (links to download the citations from this article in formats compatible with various reference manager tools)

Open citations (links to open the citations from this article in various online reference manager services)