An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor
- The Sainsbury Laboratory, United Kingdom
- John Innes Centre, United Kingdom
- Imperial College London, United Kingdom
Abstract
Plants use autophagy to safeguard against infectious diseases. However, how plant pathogens interfere with autophagy related processes is unknown. Here we show that PexRD54, an effector from the Irish potato famine pathogen Phytophthora infestans, binds host autophagy protein ATG8CL to stimulate autophagosome formation. PexRD54 depletes the autophagy cargo receptor Joka2 out of ATG8CL complexes and interferes with Joka2's positive effect on pathogen defense. Thus a plant pathogen effector has evolved to antagonize a host autophagy cargo receptor in order to counteract host defenses.
Article and author information
Author details
Reviewing Editor
- Jean T Greenberg, University of Chicago, United States
Version history
- Received: August 15, 2015
- Accepted: January 13, 2016
- Accepted Manuscript published: January 14, 2016 (version 1)
- Version of Record published: February 23, 2016 (version 2)
- Version of Record updated: October 6, 2016 (version 3)
Copyright
© 2016, Dagdas et al.
This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.
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An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor
eLife 5:e10856.
https://doi.org/10.7554/eLife.10856
