TY - JOUR TI - Neural clocks and Neuropeptide F/Y regulate circadian gene expression in a peripheral metabolic tissue AU - Erion, Renske AU - King, Anna N AU - Wu, Gang AU - Hogenesch, John B AU - Sehgal, Amita A2 - VijayRaghavan, K VL - 5 PY - 2016 DA - 2016/04/14 SP - e13552 C1 - eLife 2016;5:e13552 DO - 10.7554/eLife.13552 UR - https://doi.org/10.7554/eLife.13552 AB - Metabolic homeostasis requires coordination between circadian clocks in different tissues. Also, systemic signals appear to be required for some transcriptional rhythms in the mammalian liver and the Drosophila fat body. Here we show that free-running oscillations of the fat body clock require clock function in the PDF-positive cells of the fly brain. Interestingly, rhythmic expression of the cytochrome P450 transcripts, sex-specific enzyme 1 (sxe1) and Cyp6a21, which cycle in the fat body independently of the local clock, depends upon clocks in neurons expressing neuropeptide F (NPF). NPF signaling itself is required to drive cycling of sxe1 and Cyp6a21 in the fat body, and its mammalian ortholog, Npy, functions similarly to regulate cycling of cytochrome P450 genes in the mouse liver. These data highlight the importance of neuronal clocks for peripheral rhythms, particularly in a specific detoxification pathway, and identify a novel and conserved role for NPF/Npy in circadian rhythms. KW - circadian rhythm KW - neuropeptide F KW - neuropeptide Y KW - cytochrome P450 KW - metabolism KW - neural clocks JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -