TY - JOUR TI - Genetic dissection of the Transcription Factor code controlling serial specification of muscle identities in Drosophila AU - Dubois, Laurence AU - Frendo, Jean-Louis AU - Chanut-Delalande, Hélène AU - Crozatier, Michèle AU - Vincent, Alain A2 - Buckingham, Margaret VL - 5 PY - 2016 DA - 2016/07/20 SP - e14979 C1 - eLife 2016;5:e14979 DO - 10.7554/eLife.14979 UR - https://doi.org/10.7554/eLife.14979 AB - Each Drosophila muscle is seeded by one Founder Cell issued from terminal division of a Progenitor Cell (PC). Muscle identity reflects the expression by each PC of a specific combination of identity Transcription Factors (iTFs). Sequential emergence of several PCs at the same position raised the question of how developmental time controlled muscle identity. Here, we identified roles of Anterior Open and ETS domain lacking in controlling PC birth time and Eyes absent, No Ocelli, and Sine oculis in specifying PC identity. The windows of transcription of these and other TFs in wild type and mutant embryos, revealed a cascade of regulation integrating time and space, feed-forward loops and use of alternative transcription start sites. These data provide a dynamic view of the transcriptional control of muscle identity in Drosophila and an extended framework for studying interactions between general myogenic factors and iTFs in evolutionary diversification of muscle shapes. KW - myogenesis KW - Transcription Factors KW - regulatory networks JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -