1. Neuroscience
Download icon

Motor Circuits: Crawling towards a map of the brain

  1. Laura Masullo
  2. Marco Tripodi  Is a corresponding author
  1. MRC Laboratory of Molecular Biology, United Kingdom
Insight
Cite this article as: eLife 2016;5:e15438 doi: 10.7554/eLife.15438
1 figure

Figures

A neural circuit for crawling in fruit fly larvae.

(A) The motor neurons (MN) in a given body segment trigger the contraction of abdominal muscles in that segment (orange). Two other neurons control each motor neuron: the A27h neuron (dark blue) activates the motor neuron, and the GDL neuron (light blue) inhibits the A27h neuron. The circuit formed by these three neurons also receives input from the brain (descending input), input from other segmental neurons (not shown) and feedback signals from muscle (somatosensory input). These three inputs are likely to modulate the speed of locomotion. (B) In order to generate a locomotion pattern such as crawling, it is essential to orchestrate the contraction of muscles along the body. During forward movement, the A27h neuron in a given segment is active and drives contraction of the corresponding muscles (black: active elements, white: inactive elements). It also activates the GDL neuron in the next segment, which inactivates the corresponding A27h neuron and prevents the muscles in this segment from contracting at the same time. Then, A27h activity in the first segment declines, which relieves the inhibition of A27h in the second segment and allows the muscles to contract. P → A: posterior (back) to anterior (front)

Download links

A two-part list of links to download the article, or parts of the article, in various formats.

Downloads (link to download the article as PDF)

Download citations (links to download the citations from this article in formats compatible with various reference manager tools)

Open citations (links to open the citations from this article in various online reference manager services)