1. Cell Biology
  2. Human Biology and Medicine
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Cancer Metabolism: Partners in the Warburg effect

  1. Joshua D Rabinowitz  Is a corresponding author
  2. Hilary A Coller
  1. Princeton University, United States
  2. University of California, Los Angeles, United States
  3. David Geffen School of Medicine, United States
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Cite this article as: eLife 2016;5:e15938 doi: 10.7554/eLife.15938
1 figure

Figures

Fibroblasts supply nutrients to cancer cells and inhibit oxidative phosphorylation in cancer cells.

Fibroblasts (pink cells) associate with epithelial cancer cells (blue cells) and release exosomes (circles) that transfer nutrients to epithelial cancer cells (orange lines). In addition, they inhibit mitochondrial oxidative phosphorylation in the cancer cells (black blunt arrows), perhaps via microRNAs that silence particular genes.

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