TY - JOUR TI - Perceptually relevant remapping of human somatotopy in 24 hours AU - Kolasinski, James AU - Makin, Tamar R AU - Logan, John P AU - Jbabdi, Saad AU - Clare, Stuart AU - Stagg, Charlotte J AU - Johansen-Berg, Heidi A2 - Ivry, Richard VL - 5 PY - 2016 DA - 2016/12/30 SP - e17280 C1 - eLife 2016;5:e17280 DO - 10.7554/eLife.17280 UR - https://doi.org/10.7554/eLife.17280 AB - Experience-dependent reorganisation of functional maps in the cerebral cortex is well described in the primary sensory cortices. However, there is relatively little evidence for such cortical reorganisation over the short-term. Using human somatosensory cortex as a model, we investigated the effects of a 24 hr gluing manipulation in which the right index and right middle fingers (digits 2 and 3) were adjoined with surgical glue. Somatotopic representations, assessed with two 7 tesla fMRI protocols, revealed rapid off-target reorganisation in the non-manipulated fingers following gluing, with the representation of the ring finger (digit 4) shifted towards the little finger (digit 5) and away from the middle finger (digit 3). These shifts were also evident in two behavioural tasks conducted in an independent cohort, showing reduced sensitivity for discriminating the temporal order of stimuli to the ring and little fingers, and increased substitution errors across this pair on a speeded reaction time task. KW - somatosensory KW - plasticity KW - topography JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -