1. Immunology and Inflammation
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Innate Like Lymphocytes: Moving at the frontline

  1. Marco Ataíde
  2. Wolfgang Kastenmüller  Is a corresponding author
  1. University of Bonn, Germany
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Cite this article as: eLife 2016;5:e20516 doi: 10.7554/eLife.20516
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The positioning of innate-like T lymphocytes in the lymph node is crucial for defending against pathogens.

Lymphatic epithelial cells (green) release the chemokine CCL20, resulting in a gradient in the lymph node that acts as a cue for innate-like T lymphocytes with CCR6 receptors on their surface (CCR6+; ochre cells) to migrate toward the subcapsular sinus area (the region of the lymph node where lymph enters the tissue). There, the innate-like T lymphocytes can sense interleukin-1β (IL-1β) that the macrophages that line the sinus (blue cells) release locally in response to the activation of the inflammasome. Together with interleukin-23 (not shown), IL-1β activates the CCR6+ innate-like lymphocytes, which in turn produce interleukin-17 (IL-17). IL-17 is a critical factor for microbial defense because it promotes the recruitment of other innate immune cells – neutrophils and monocytes. The graphical illustration was designed and kindly provided by Karl Komander.

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