1. Chromosomes and Gene Expression
  2. Genetics and Genomics
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Craniosynostosis: An epistatic explanation

  1. Yoshihiro Komatsu
  2. Yuji Mishina  Is a corresponding author
  1. The University of Texas Medical School at Houston, United States
  2. University of Michigan, United States
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Cite this article as: eLife 2016;5:e21162 doi: 10.7554/eLife.21162
1 figure

Figures

3D reconstructions of the skull shapes that result from two types of non-syndromic craniosynostosis.

Top row: In metopic craniosynostosis, the metopic suture that passes down the middle of the forehead fuses prematurely. This results in a narrow forehead that forms with a ridge down the suture. In an attempt to compensate, the skull grows in a way that pushes the forehead forward. Bottom row: sagittal craniosynostosis results from the premature fusion of the sagittal suture along the top of the skull. As a result, the skull stays narrow and extends toward the front and back to compensate.

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