TY - JOUR TI - mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice AU - Burke, Luke K AU - Darwish, Tamana AU - Cavanaugh, Althea R AU - Virtue, Sam AU - Roth, Emma AU - Morro, Joanna AU - Liu, Shun-Mei AU - Xia, Jing AU - Dalley, Jeffrey W AU - Burling, Keith AU - Chua, Streamson AU - Vidal-Puig, Toni AU - Schwartz, Gary J AU - Blouet, Clémence A2 - Elmquist, Joel K VL - 6 PY - 2017 DA - 2017/05/23 SP - e22848 C1 - eLife 2017;6:e22848 DO - 10.7554/eLife.22848 UR - https://doi.org/10.7554/eLife.22848 AB - Energy dissipation through interscapular brown adipose tissue (iBAT) thermogenesis is an important contributor to adaptive energy expenditure. However, it remains unresolved how acute and chronic changes in energy availability are detected by the brain to adjust iBAT activity and maintain energy homeostasis. Here, we provide evidence that AGRP inhibitory tone to iBAT represents an energy-sparing circuit that integrates environmental food cues and internal signals of energy availability. We establish a role for the nutrient-sensing mTORC1 signaling pathway within AGRP neurons in the detection of environmental food cues and internal signals of energy availability, and in the bi-directional control of iBAT thermogenesis during nutrient deficiency and excess. Collectively, our findings provide insights into how mTORC1 signaling within AGRP neurons surveys energy availability to engage iBAT thermogenesis, and identify AGRP neurons as a neuronal substrate for the coordination of energy intake and adaptive expenditure under varying physiological and environmental contexts. KW - obesity KW - hypothalamus KW - energy expenditure KW - brown fat KW - nutrient-sensing KW - mTORC1 JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -