Chemical structure-guided design of dynapyrazoles, potent cell-permeable dynein inhibitors with a unique mode of action

  1. Jonathan Baruch Steinman
  2. Cristina C Santarossa
  3. Rand M Miller
  4. Lola S Yu
  5. Anna S Serpinskaya
  6. Hideki Furukawa
  7. Sachie Morimoto
  8. Yuta Tanaka
  9. Mitsuyoshi Nishitani
  10. Moriteru Asano
  11. Ruta Zalyte
  12. Alison E Ondrus
  13. Alex G Johnson
  14. Fan Ye
  15. Maxence V Nachury
  16. Yoshiyuki Fukase
  17. Kazuyoshi Aso
  18. Michael A Foley
  19. Vladimir I Gelfand
  20. James K Chen
  21. Andrew P Carter
  22. Tarun M Kapoor  Is a corresponding author
  1. Rockefeller University, United States
  2. Feinberg School of Medicine, Northwestern University, United States
  3. Tri-Institutitional Therapeutics Discovery Institute, United States
  4. Takeda Pharmaceuticals Ltd., Japan
  5. MRC Laboratory of Molecular Biology, United Kingdom
  6. California Institute of Technology, United States
  7. Stanford University, United States
  8. Stanford University School of Medicine, United States
  9. Northwestern University, United States
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  1. Jonathan Baruch Steinman
  2. Cristina C Santarossa
  3. Rand M Miller
  4. Lola S Yu
  5. Anna S Serpinskaya
  6. Hideki Furukawa
  7. Sachie Morimoto
  8. Yuta Tanaka
  9. Mitsuyoshi Nishitani
  10. Moriteru Asano
  11. Ruta Zalyte
  12. Alison E Ondrus
  13. Alex G Johnson
  14. Fan Ye
  15. Maxence V Nachury
  16. Yoshiyuki Fukase
  17. Kazuyoshi Aso
  18. Michael A Foley
  19. Vladimir I Gelfand
  20. James K Chen
  21. Andrew P Carter
  22. Tarun M Kapoor
(2017)
Chemical structure-guided design of dynapyrazoles, potent cell-permeable dynein inhibitors with a unique mode of action
eLife 6:e25174.
https://doi.org/10.7554/eLife.25174