TY - JOUR TI - Reactive oxygen species-dependent Toll/NF-κB activation in the Drosophila hematopoietic niche confers resistance to wasp parasitism AU - Louradour, Isabelle AU - Sharma, Anurag AU - Morin-Poulard, Ismael AU - Letourneau, Manon AU - Vincent, Alain AU - Crozatier, Michèle AU - Vanzo, Nathalie A2 - Lemaître, Bruno VL - 6 PY - 2017 DA - 2017/11/01 SP - e25496 C1 - eLife 2017;6:e25496 DO - 10.7554/eLife.25496 UR - https://doi.org/10.7554/eLife.25496 AB - Hematopoietic stem/progenitor cells in the adult mammalian bone marrow ensure blood cell renewal. Their cellular microenvironment, called ‘niche’, regulates hematopoiesis both under homeostatic and immune stress conditions. In the Drosophila hematopoietic organ, the lymph gland, the posterior signaling center (PSC) acts as a niche to regulate the hematopoietic response to immune stress such as wasp parasitism. This response relies on the differentiation of lamellocytes, a cryptic cell type, dedicated to pathogen encapsulation and killing. Here, we establish that Toll/NF-κB pathway activation in the PSC in response to wasp parasitism non-cell autonomously induces the lymph gland immune response. Our data further establish a regulatory network where co-activation of Toll/NF-κB and EGFR signaling by ROS levels in the PSC/niche controls lymph gland hematopoiesis under parasitism. Whether a similar regulatory network operates in mammals to control emergency hematopoiesis is an open question. KW - Toll/NF-kB pathway KW - hematopoiesis KW - parasitism KW - Drosophila JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -