TY - JOUR TI - Synthesizing artificial devices that redirect cellular information at will AU - Liu, Yuchen AU - Li, Jianfa AU - Chen, Zhicong AU - Huang, Weiren AU - Cai, Zhiming A2 - Barkai, Naama VL - 7 PY - 2018 DA - 2018/01/10 SP - e31936 C1 - eLife 2018;7:e31936 DO - 10.7554/eLife.31936 UR - https://doi.org/10.7554/eLife.31936 AB - Natural signaling circuits could be rewired to reprogram cells with pre-determined procedures. However, it is difficult to link cellular signals at will. Here, we describe signal-connectors—a series of RNA devices—that connect one signal to another signal at the translational level. We use them to either repress or enhance the translation of target genes in response to signals. Application of these devices allows us to construct various logic gates and to incorporate feedback loops into gene networks. They have also been used to rewire a native signaling pathway and even to create novel pathways. Furthermore, logical AND gates based on these devices and integration of multiple signals have been used successfully for identification and redirection of the state of cancer cells. Eventually, the malignant phenotypes of cancers have been reversed by rewiring the oncogenic signaling from promoting to suppressing tumorigenesis. We provide a novel platform for redirecting cellular information. KW - cancer biology KW - signaling networks KW - genetic switch JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -