TY - JOUR TI - Eye opening differentially modulates inhibitory synaptic transmission in the developing visual cortex AU - Guan, Wuqiang AU - Cao, Jun-Wei AU - Liu, Lin-Yun AU - Zhao, Zhi-Hao AU - Fu, Yinghui AU - Yu, Yong-Chun A2 - Bartos, Marlene VL - 6 PY - 2017 DA - 2017/12/11 SP - e32337 C1 - eLife 2017;6:e32337 DO - 10.7554/eLife.32337 UR - https://doi.org/10.7554/eLife.32337 AB - Eye opening, a natural and timed event during animal development, influences cortical circuit assembly and maturation; yet, little is known about its precise effect on inhibitory synaptic connections. Here, we show that coinciding with eye opening, the strength of unitary inhibitory postsynaptic currents (uIPSCs) from somatostatin-expressing interneurons (Sst-INs) to nearby excitatory neurons, but not interneurons, sharply decreases in layer 2/3 of the mouse visual cortex. In contrast, the strength of uIPSCs from fast-spiking interneurons (FS-INs) to excitatory neurons significantly increases during eye opening. More importantly, these developmental changes can be prevented by dark rearing or binocular lid suture, and reproduced by the artificial opening of sutured lids. Mechanistically, this differential maturation of synaptic transmission is accompanied by a significant change in the postsynaptic quantal size. Together, our study reveals a differential regulation in GABAergic circuits in the cortex driven by eye opening may be crucial for cortical maturation and function. KW - eye opening KW - synaptic transmission KW - somatostatin-expressing interneurons KW - fast-spiking interneurons KW - development JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -