TY - JOUR TI - Ecological multiplex interactions determine the role of species for parasite spread amplification AU - Stella, Massimo AU - Selakovic, Sanja AU - Antonioni, Alberto AU - Andreazzi, Cecilia S A2 - Gottdenker, Nicole VL - 7 PY - 2018 DA - 2018/04/23 SP - e32814 C1 - eLife 2018;7:e32814 DO - 10.7554/eLife.32814 UR - https://doi.org/10.7554/eLife.32814 AB - Despite their potential interplay, multiple routes of many disease transmissions are often investigated separately. As a unifying framework for understanding parasite spread through interdependent transmission paths, we present the ‘ecomultiplex’ model, where the multiple transmission paths among a diverse community of interacting hosts are represented as a spatially explicit multiplex network. We adopt this framework for designing and testing potential control strategies for Trypanosoma cruzi spread in two empirical host communities. We show that the ecomultiplex model is an efficient and low data-demanding method to identify which species enhances parasite spread and should thus be a target for control strategies. We also find that the interplay between predator-prey and host-parasite interactions leads to a phenomenon of parasite amplification, in which top predators facilitate T. cruzi spread, offering a mechanistic interpretation of previous empirical findings. Our approach can provide novel insights in understanding and controlling parasite spreading in real-world complex systems. KW - ecological multiplex networks KW - multi-layer networks KW - parasite spreading KW - multi-host parasites KW - multiple routes of transmission KW - immunisation strategies JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -