1. Structural Biology and Molecular Biophysics
  2. Microbiology and Infectious Disease
Download icon

Vaccine Design: Chimeras could help in the fight against leptospirosis

  1. Jademilson C Santos
  2. Ana Lucia TO Nascimento  Is a corresponding author
  1. Instituto Butantan, Brazil
Insight
Cite this article as: eLife 2018;7:e34087 doi: 10.7554/eLife.34087
1 figure

Figures

Schematic representation of how structural biology contributes to vaccine design.

Sequencing the genome of a pathogen (top left) makes it possible to clone protein-based antigens – the features of the pathogen that are detected by antibodies in the host immune system. When mice are injected with the purified antigens, cells in their spleen produce monoclonal antibodies (mAbs) via cells called hybridomas. By studying the structure of the antibodies, and identifying the regions that interact most strongly with the antigens, researchers can build chimeric proteins from these regions. The effectiveness of the chimera as a vaccine for the pathogen can then be tested in animal models and human clinical trials.

Download links

A two-part list of links to download the article, or parts of the article, in various formats.

Downloads (link to download the article as PDF)

Download citations (links to download the citations from this article in formats compatible with various reference manager tools)

Open citations (links to open the citations from this article in various online reference manager services)