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Correction: Replication Study: Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

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Cite this article as: eLife 2018;7:e34573 doi: 10.7554/eLife.34573

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Shan X, Fung JJ, Kosaka A, Danet-Desnoyers G, Reproducibility Project: Cancer Biology. 2017. Replication Study: Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. eLife 6:e25306. doi: 10.7554/eLife.25306.

Published 27, June 2017

This is a corrigendum for Replication Study: Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia, which includes the following corrections:

First, the direction of the effect size calculated for the Replication Study’s comparison of fold BCL2 expression in K-562 cells compared to a DMSO constant of 1 (Figure 5A, top panel) is incorrect. The direction of the effect size (Cohen’s d) for this comparison should be d = −2.04 95% CI [−4.17, 0.13] (instead of the reported d = 2.04 95% CI [−0.13, 4.17]), which results in a change in the meta-analysis. The meta-analysis effect size should be d = −0.307, 95% CI [−3.57, 2.96], p =0.854 (instead of the reported d = 1.58, 95% CI [0.36, 2.79], p=0.011).

Second, the calculation of variance in the meta-analysis of mice treated daily with I-BET151 compared to vehicle control mice (Figure 5C) is incorrect. Subsequently, the effect size and the associated p value of the meta-analysis are incorrect. The effect size (Hazard Ratio) for this comparison should be HR = 3.30 95% CI [0.49, 22.18] (instead of the reported HR = 6.13 95% CI [1.11, 34.02]) resulting in a p value of p=0.220 (instead of the reported p = 0.038).

Finally, the language surrounding these comparisons in the Results and Discussion section as well as in Figure 5 and the Figure Legend (Figure 5) have been amended to account for these corrections. Additional r code for the meta-analysis can be found on the Open Science Framework: https://osf.io/vfp47/.

The corrected Figure 5 is shown here:

The originally published Figure 5 is also shown for reference:

The article has now been corrected.

Article and author information

Author details

  1. Xiaochuan Shan

  2. Juan José Fung

  3. Alan Kosaka

  4. Gwenn Danet-Desnoyers

  5. Reproducibility Project: Cancer Biology

    For correspondence
    tim@cos.io

Publication history

  1. Received: January 3, 2018
  2. Accepted: January 3, 2018
  3. Version of Record published: January 8, 2018 (version 1)

Copyright

© 2018, Shan et al.

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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