1. Structural Biology and Molecular Biophysics
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Molecular Chaperones: Confirmation for conformational selection

  1. Yajun Jiang
  2. Charalampos G Kalodimos  Is a corresponding author
  1. St Jude Children's Research Hospital, United States
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Cite this article as: eLife 2018;7:e34923 doi: 10.7554/eLife.34923
1 figure

Figures

Cartoon illustrations of the conformational selection and induced fit mechanisms.

(A) In the conformational selection mechanism, the substrate (blue) switches between different conformations, and the chaperone (green) selectively interacts with one of these conformations. (B). In the induced fit mechanism, the chaperone directly interacts with the substrate, irrespective of the latter's conformation, and then changes its conformation.

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