TY - JOUR TI - Content-specific activity in frontoparietal and default-mode networks during prior-guided visual perception AU - González-García, Carlos AU - Flounders, Matthew W AU - Chang, Raymond AU - Baria, Alexis T AU - He, Biyu J A2 - Marder, Eve A2 - Culham, Jody C VL - 7 PY - 2018 DA - 2018/07/31 SP - e36068 C1 - eLife 2018;7:e36068 DO - 10.7554/eLife.36068 UR - https://doi.org/10.7554/eLife.36068 AB - How prior knowledge shapes perceptual processing across the human brain, particularly in the frontoparietal (FPN) and default-mode (DMN) networks, remains unknown. Using ultra-high-field (7T) functional magnetic resonance imaging (fMRI), we elucidated the effects that the acquisition of prior knowledge has on perceptual processing across the brain. We observed that prior knowledge significantly impacted neural representations in the FPN and DMN, rendering responses to individual visual images more distinct from each other, and more similar to the image-specific prior. In addition, neural representations were structured in a hierarchy that remained stable across perceptual conditions, with early visual areas and DMN anchored at the two extremes. Two large-scale cortical gradients occur along this hierarchy: first, dimensionality of the neural representational space increased along the hierarchy; second, prior’s impact on neural representations was greater in higher-order areas. These results reveal extensive and graded influences of prior knowledge on perceptual processing across the brain. KW - visual perception KW - prior experience KW - default-mode network KW - frontoparietal network KW - 7T fMRI JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -