TY - JOUR TI - Histone H3 threonine 11 phosphorylation by Sch9 and CK2 regulates chronological lifespan by controlling the nutritional stress response AU - Oh, Seunghee AU - Suganuma, Tamaki AU - Gogol, Madelaine M AU - Workman, Jerry L A2 - Kaeberlein, Matt VL - 7 PY - 2018 DA - 2018/06/25 SP - e36157 C1 - eLife 2018;7:e36157 DO - 10.7554/eLife.36157 UR - https://doi.org/10.7554/eLife.36157 AB - Upon nutritional stress, the metabolic status of cells is changed by nutrient signaling pathways to ensure survival. Altered metabolism by nutrient signaling pathways has been suggested to influence cellular lifespan. However, it remains unclear how chromatin regulation is involved in this process. Here, we found that histone H3 threonine 11 phosphorylation (H3pT11) functions as a marker for nutritional stress and aging. Sch9 and CK2 kinases cooperatively regulate H3pT11 under stress conditions. Importantly, H3pT11 defective mutants prolonged chronological lifespan (CLS) by altering nutritional stress responses. Thus, the phosphorylation of H3T11 by Sch9 and CK2 links a nutritional stress response to chromatin in the regulation of CLS. KW - histone KW - phosphorylation KW - metabolism KW - aging KW - casein kinase KW - sch9 JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -