TY - JOUR TI - TFAP2 transcription factors are regulators of lipid droplet biogenesis AU - Scott, Cameron C AU - Vossio, Stefania AU - Rougemont, Jacques AU - Gruenberg, Jean A2 - Walther, Tobias C A2 - Malhotra, Vivek VL - 7 PY - 2018 DA - 2018/09/26 SP - e36330 C1 - eLife 2018;7:e36330 DO - 10.7554/eLife.36330 UR - https://doi.org/10.7554/eLife.36330 AB - How trafficking pathways and organelle abundance adapt in response to metabolic and physiological changes is still mysterious, although a few transcriptional regulators of organellar biogenesis have been identified in recent years. We previously found that the Wnt signaling directly controls lipid droplet formation, linking the cell storage capacity to the established functions of Wnt in development and differentiation. In the present paper, we report that Wnt-induced lipid droplet biogenesis does not depend on the canonical TCF/LEF transcription factors. Instead, we find that TFAP2 family members mediate the pro-lipid droplet signal induced by Wnt3a, leading to the notion that the TFAP2 transcription factor may function as a ‘master’ regulator of lipid droplet biogenesis. KW - Wnt signaling KW - organelle biogenesis KW - lipid droplet JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -