TY - JOUR TI - Intermittent subthalamic nucleus deep brain stimulation induces risk-aversive behavior in human subjects AU - Patel, Shaun R AU - Herrington, Todd M AU - Sheth, Sameer A AU - Mian, Matthew AU - Bick, Sarah K AU - Yang, Jimmy C AU - Flaherty, Alice W AU - Frank, Michael J AU - Widge, Alik S AU - Dougherty, Darin AU - Eskandar, Emad N A2 - Stuphorn, Veit A2 - Ivry, Richard B A2 - Forstmann, Birte VL - 7 PY - 2018 DA - 2018/09/10 SP - e36460 C1 - eLife 2018;7:e36460 DO - 10.7554/eLife.36460 UR - https://doi.org/10.7554/eLife.36460 AB - The subthalamic nucleus (STN) is a small almond-shaped subcortical structure classically known for its role in motor inhibition through the indirect pathway within the basal ganglia. Little is known about the role of the STN in mediating cognitive functions in humans. Here, we explore the role of the STN in human subjects making decisions under conditions of uncertainty using single-neuron recordings and intermittent deep brain stimulation (DBS) during a financial decision-making task. Intraoperative single-neuronal data from the STN reveals that on high-uncertainty trials, spiking activity encodes the upcoming decision within a brief (500 ms) temporal window during the choice period, prior to the manifestation of the choice. Application of intermittent DBS selectively prior to the choice period alters decisions and biases subject behavior towards conservative wagers. KW - subthalamic nucleus KW - neurophysiology KW - fMRI KW - human KW - decision-making KW - deep brain stimulation JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -