Unravelling the history of hepatitis B virus genotypes A and D infection using a full-genome phylogenetic and phylogeographic approach

Abstract
Data availability
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Abstract

Hepatitis B virus (HBV) infection constitutes a global public health problem. In order to establish how HBV was disseminated across different geographic regions, we estimated the levels of regional clustering for genotypes D and A. We used 916 HBV-D and 493 HBV-A full-length sequences to reconstruct their global phylogeny. Phylogeographic analysis was conducted by reconstruction of ancestral states using the criterion of parsimony. The putative origin of genotype D was in North Africa/Middle East. HBV-D sequences form low levels of regional clustering for the Middle East and Southern Europe. In contrast, HBV-A sequences form two major clusters, the first including sequences mostly from sub-Saharan Africa, and the second including sequences mostly from Western and Central Europe. Conclusion: We observed considerable differences in the global dissemination patterns of HBV-D and HBV-A and different levels of monophyletic clustering in relation to the regions of prevalence of each genotype.

Data availability

All data (sequence alignments and additional pieces of information related to the accession numbers of sequences and their sampling areas) are available at Dryad (doi: 10.5061/dryad.bt4q242).

The following data sets were generated

1. Kostaki E
2. Karamitros T
3. Stefanou G
4. Mamais I
5. Angelis K
6. Hatzakis A
7. Kramvis A
8. Paraskevis D
(2018) Data from: Unravelling the history of hepatitis B virus genotypes A and D infection using a full-genome phylogenetic and phylogeographic approach
Available at Dryad Digital Repository under a CC0 Public Domain Dedication.

http://dx.doi.org/10.5061/dryad.bt4q242

Article and author information

Author details

Evangelia-Georgia Kostaki

Department of Hygiene, Epidemiology and Medical Statistics, National and Kapodistrian University of Athens, Athens, Greece

Competing interests
The authors declare that no competing interests exist.
Timokratis Karamitros

Department of Hygiene, Epidemiology and Medical Statistics, National and Kapodistrian University of Athens, Athens, Greece

Competing interests
The authors declare that no competing interests exist.

"This ORCID iD identifies the author of this article:" 0000-0003-0841-9159
Garyfallia Stefanou

Department of Hygiene, Epidemiology and Medical Statistics, National and Kapodistrian University of Athens, Athens, Greece

Competing interests
The authors declare that no competing interests exist.
Ioannis Mamais

Department of Health Sciences, School of Sciences, European University of Cyprus, Nicosia, Cyprus

Competing interests
The authors declare that no competing interests exist.
Konstantinos Angelis

Department of Hygiene, Epidemiology and Medical Statistics, National and Kapodistrian University of Athens, Athens, Greece

Competing interests
The authors declare that no competing interests exist.
Angelos Hatzakis

Department of Hygiene, Epidemiology and Medical Statistics, National and Kapodistrian University of Athens, Athens, Greece

Competing interests
The authors declare that no competing interests exist.
Anna Kramvis

Hepatitis Virus Diversity Research Unit, Department of Internal Medicine, University of the Witwatersrand, Johannesburg, South Africa

Competing interests
The authors declare that no competing interests exist.
Dimitrios Paraskevis

Department of Hygiene, Epidemiology and Medical Statistics, National and Kapodistrian University of Athens, Athens, Greece

For correspondence
dparask@med.uoa.gr

Competing interests
The authors declare that no competing interests exist.

"This ORCID iD identifies the author of this article:" 0000-0001-6167-7152

Funding

Hellenic Scientific Society for the Study of AIDS and STDs

Evangelia-Georgia Kostaki
Timokratis Karamitros
Garyfallia Stefanou
Ioannis Mamais
Konstantinos Angelis
Angelos Hatzakis
Anna Kramvis
Dimitrios Paraskevis

The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

Copyright

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.