Comment on "YcgC represents a new protein deacetylase family in prokaryotes"

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Abstract

Lysine acetylation is a post-translational modification that is conserved from bacteria to humans. It is catalysed by the activities of lysine acetyltransferases, which use acetyl-CoA as the acetyl-donor molecule, and lysine deacetylases, which remove the acetyl moiety. Recently, it was reported that YcgC represents a new prokaryotic deacetylase family with no apparent homologies to existing deacetylases (Tu et al., 2015). Here we report the results of experiments which demonstrate that YcgC is not a deacetylase.

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All data generated or analyses during this study are included in the manuscript and supporting files.

Article and author information

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Magdalena Kremer

Institute for Genetics, CECAD Research Center, University of Cologne, Cologne, Germany

Competing interests
The authors declare that no competing interests exist.
Kuhlmann Nora

Institute for Genetics, CECAD Research Center, University of Cologne, Cologne, Germany

Competing interests
The authors declare that no competing interests exist.
Marius Lechner

Institute for Genetics, CECAD Research Center, University of Cologne, Cologne, Germany

Competing interests
The authors declare that no competing interests exist.
Linda Baldus

Institute for Genetics, CECAD Research Center, University of Cologne, Cologne, Germany

Competing interests
The authors declare that no competing interests exist.
Michael Lammers

Institute for Genetics, CECAD Research Center, University of Cologne, Cologne, Germany

For correspondence
michael.lammers@uni-koeln.de

Competing interests
The authors declare that no competing interests exist.

"This ORCID iD identifies the author of this article:" 0000-0003-4168-4640

Funding

Deutsche Forschungsgemeinschaft (LA 2984/3-1)

Michael Lammers

Deutsche Forschungsgemeinschaft (CECAD)

Magdalena Kremer
Kuhlmann Nora
Marius Lechner
Linda Baldus
Michael Lammers

Boehringer Ingelheim Fonds (Exploration Grant)

Kuhlmann Nora

Deutsche Forschungsgemeinschaft (Cologne Graduate School of Ageing Research)

Magdalena Kremer

The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

Copyright

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.