TY - JOUR TI - CA2 neuronal activity controls hippocampal low gamma and ripple oscillations AU - Alexander, Georgia M AU - Brown, Logan Y AU - Farris, Shannon AU - Lustberg, Daniel AU - Pantazis, Caroline AU - Gloss, Bernd AU - Plummer, Nicholas W AU - Jensen, Patricia AU - Dudek, Serena M A2 - Colgin, Laura A2 - Gold, Joshua I VL - 7 PY - 2018 DA - 2018/11/02 SP - e38052 C1 - eLife 2018;7:e38052 DO - 10.7554/eLife.38052 UR - https://doi.org/10.7554/eLife.38052 AB - Hippocampal oscillations arise from coordinated activity among distinct populations of neurons and are associated with cognitive functions. Much progress has been made toward identifying the contribution of specific neuronal populations in hippocampal oscillations, but less is known about the role of hippocampal area CA2, which is thought to support social memory. Furthermore, the little evidence on the role of CA2 in oscillations has yielded conflicting conclusions. Therefore, we sought to identify the contribution of CA2 to oscillations using a controlled experimental system. We used excitatory and inhibitory DREADDs to manipulate CA2 neuronal activity and studied resulting hippocampal-prefrontal cortical network oscillations. We found that modification of CA2 activity bidirectionally regulated hippocampal and prefrontal cortical low-gamma oscillations and inversely modulated hippocampal ripple oscillations in mice. These findings support a role for CA2 in low-gamma generation and ripple modulation within the hippocampus and underscore the importance of CA2 in extrahippocampal oscillations. KW - Hippocampal CA2 KW - DREADD KW - hM3Dq KW - hM4Di KW - gamma oscillation KW - ripple JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -