An initial cue signaled potential gain for each trial (high/low pleasure erotic picture or high/low monetary reward). After a variable delay, a target briefly appeared. Responding during target …
Top row: Pleasure and frustration ratings for received and missed monetary rewards. Bottom row: Pleasure and frustration ratings for received and missed erotic picture rewards.
Data is shown for n = 14 volunteers during the placebo treatment only, because naloxone is known to directly affect autonomic regulation of SCR (Traore et al., 1998).
Frustration ratings for missed erotic rewards show a stronger decrease by naloxone as compared to monetary rewards (right). (* denotes p<0.05; * between bars denote p<0.05 for the interaction).
Under naloxone treatment, activation in the ventral striatum, medial prefrontal cortex lateral orbitofrontal cortex, the amygdala and the hypothalamus is significantly reduced. This reduction is …
**p<0.05 corrected for multiple comparisons; *p<0.05 uncorrected.
Error bars represent standard error of the mean.
Error bars represent standard error of the mean.
Error bars represent standard error of the mean.
Error bars represent standard error of the mean.
Error bars represent standard error of the mean.
Error bars represent standard error of the mean.
Error bars represent standard error of the mean.
Error bars represent standard error of the mean.
The more naloxone reduced fMRI signal comparing high versus low erotic rewards during outcome, the more the rating difference between high and low erotic rewards was reduced (See also Table S10). …
Side effects ratings.
Two sided paired Wilcoxon signed rank test comparing mood between naloxone (_nlx) and saline (_nacl) sessions.
Mood ratings.
Two sided paired Wilcoxon signed rank test comparing mood between naloxone (_nlx) and saline (_nacl) sessions.
Rating differences for successful and missed reward trials in the placebo treatment condition.
Effects of Naloxone on pleasure ratings.
Repeated measures ANOVA, Huynh-Feldt nonsphericity correction.
Naloxone effects (relative to placebo) on pleasure ratings.
Coordinates from individual studies to define the center of ROIs.
Naloxone effects (relative to placebo) on the high versus low erotic image outcome contrast.
Naloxone effects (relative to placebo) comparing erotic versus monetary outcomes.
Naloxone effects (relative to placebo) on other contrasts.
Regression analysis relating the change in pleasure ratings to the change in fMRI signal.