1. Cancer Biology
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Cancer Immunotherapy: A peptide puzzle

  1. Jian Guan
  2. Nilabh Shastri  Is a corresponding author
  1. Johns Hopkins School of Medicine, United States
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Cite this article as: eLife 2018;7:e41524 doi: 10.7554/eLife.41524
1 figure

Figures

Schematic illustration of the anti-cancer immune response.

(a) Gejman et al. found that a cancer that contains a large fraction of immunogenic tumor cells of the same type (shown in green) can be effectively rejected by the immune system of the mouse (left), whereas a cancer that contains a small fraction of immunogenic tumor cells will not be rejected (right). (b) However, a cancer that contains a large fraction of immunogenic tumor cells of different types (shown in different colors) will not be rejected. This behavior observed by Gejman et al. in mice is similar to that seen in humans who do not respond to immunotherapy (McGranahan et al., 2016).

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