TY - JOUR TI - Two central pattern generators from the crab, Cancer borealis, respond robustly and differentially to extreme extracellular pH AU - Haley, Jessica A AU - Hampton, David AU - Marder, Eve A2 - Calabrese, Ronald L VL - 7 PY - 2018 DA - 2018/12/28 SP - e41877 C1 - eLife 2018;7:e41877 DO - 10.7554/eLife.41877 UR - https://doi.org/10.7554/eLife.41877 AB - The activity of neuronal circuits depends on the properties of the constituent neurons and their underlying synaptic and intrinsic currents. We describe the effects of extreme changes in extracellular pH – from pH 5.5 to 10.4 – on two central pattern generating networks, the stomatogastric and cardiac ganglia of the crab, Cancer borealis. Given that the physiological properties of ion channels are known to be sensitive to pH within the range tested, it is surprising that these rhythms generally remained robust from pH 6.1 to pH 8.8. The pH sensitivity of these rhythms was highly variable between animals and, unexpectedly, between ganglia. Animal-to-animal variability was likely a consequence of similar network performance arising from variable sets of underlying conductances. Together, these results illustrate the potential difficulty in generalizing the effects of environmental perturbation across circuits, even within the same animal. KW - Cancer borealis KW - stomatogastric ganglion KW - cardiac ganglion KW - pyloric rhythm KW - crustacean KW - ocean acidification JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -