TY - JOUR TI - Associations between sounds and actions in early auditory cortex of nonhuman primates AU - Huang, Ying AU - Heil, Peter AU - Brosch, Michael A2 - Behrens, Timothy E A2 - Averbeck, Bruno B A2 - David, Stephen V A2 - Petkov, Christopher I VL - 8 PY - 2019 DA - 2019/04/04 SP - e43281 C1 - eLife 2019;8:e43281 DO - 10.7554/eLife.43281 UR - https://doi.org/10.7554/eLife.43281 AB - An individual may need to take different actions to the same stimulus in different situations to achieve a given goal. The selection of the appropriate action hinges on the previously learned associations between stimuli, actions, and outcomes in the situations. Here, using a go/no-go paradigm and a symmetrical reward, we show that early auditory cortex of nonhuman primates represents such associations, in both the spiking activity and the local field potentials. Sound-evoked neuronal responses changed with sensorimotor associations shortly after sound onset, and the neuronal responses were largest when the sound signaled that a no-go response was required in a trial to obtain a reward. Our findings suggest that association processes take place in the auditory system and do not necessarily rely on association cortex. Thus, auditory cortex may contribute to a rapid selection of the appropriate motor responses to sounds during goal-directed behavior. KW - monkeys KW - Macaca fascicularis KW - nonhuman primates JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -