TY - JOUR TI - Rapid task-dependent tuning of the mouse olfactory bulb AU - Koldaeva, Anzhelika AU - Schaefer, Andreas T AU - Fukunaga, Izumi A2 - Uchida, Naoshige A2 - Westbrook, Gary L A2 - Uchida, Naoshige VL - 8 PY - 2019 DA - 2019/02/06 SP - e43558 C1 - eLife 2019;8:e43558 DO - 10.7554/eLife.43558 UR - https://doi.org/10.7554/eLife.43558 AB - Adapting neural representation to rapidly changing behavioural demands is a key challenge for the nervous system. Here, we demonstrate that the output of the primary olfactory area of the mouse, the olfactory bulb, is already a target of dynamic and reproducible modulation. The modulation depends on the stimulus tuning of a given neuron, making olfactory responses more discriminable through selective amplification in a demand-specific way. KW - olfactory bulb KW - dynamic modulation KW - task switching JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -