TY - JOUR TI - Comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies' AU - Landegren, Nils AU - Rosen, Lindsey B AU - Freyhult, Eva AU - Eriksson, Daniel AU - Fall, Tove AU - Smith, Gustav AU - Ferre, Elise M N AU - Brodin, Petter AU - Sharon, Donald AU - Snyder, Michael AU - Lionakis, Michail AU - Anderson, Mark AU - Kämpe, Olle A2 - Rodgers, Peter A2 - Weigel, Detlef A2 - Goodnow, Christopher C VL - 8 PY - 2019 DA - 2019/06/27 SP - e43578 C1 - eLife 2019;8:e43578 DO - 10.7554/eLife.43578 UR - https://doi.org/10.7554/eLife.43578 AB - The AIRE gene plays a key role in the development of central immune tolerance by promoting thymic presentation of tissue-specific molecules. Patients with AIRE-deficiency develop multiple autoimmune manifestations and display autoantibodies against the affected tissues. In 2016 it was reported that: i) the spectrum of autoantibodies in patients with AIRE-deficiency is much broader than previously appreciated; ii) neutralizing autoantibodies to type I interferons (IFNs) could provide protection against type 1 diabetes in these patients (Meyer et al., 2016). We attempted to replicate these new findings using a similar experimental approach in an independent patient cohort, and found no evidence for either conclusion. KW - autoantigen KW - autoantibody KW - type 1 diabetes KW - immune tolerance KW - APS1/APECED JF - eLife SN - 2050-084X PB - eLife Sciences Publications, Ltd ER -