1. Cell Biology
  2. Developmental Biology
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Mechanotransduction: How muscle contraction strengthens tendons

  1. Nicole O Glenn  Is a corresponding author
  2. Clarissa A Henry  Is a corresponding author
  1. St. Jude Children's Research Hospital, United States
  2. University of Maine, United States
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Cite this article as: eLife 2019;8:e44149 doi: 10.7554/eLife.44149
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Muscle contraction is required for normal tendon development.

(A) During normal muscle development, contractions increase the amount of extracellular matrix proteins, including collagen (green) and Thrombospondin (red), deposited in the developing tendon. These muscle contractions are also required for normal BMP signaling that prompts tenocytes (tendon precursor cells, blue) to elongate and extend complex protrusions (inset panels). (B) In the absence of muscle contraction, extracellular matrix deposition is decreased and tenocytes are rounded with shorter and less complex protrusions.

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